ERK-dependent PSD-95 induction in the gustatory cortex is necessary for taste learning, but not retrieval

Alina Elkobi; Ingrid Ehrlich; Katya Belelovsky; Liza Barki-Harrington; Kobi Rosenblum

doi:10.1038/nn.2190

ERK-dependent PSD-95 induction in the gustatory cortex is necessary for taste learning, but not retrieval

Alina Elkobi, Ingrid Ehrlich, Katya Belelovsky, Liza Barki-Harrington, Kobi Rosenblum

Research output: Contribution to journal › Article › peer-review

Abstract

The processes underlying long-term memory formation in the neocortex are poorly understood. Using taste learning, we found learning-related induction of PSD-95 in the gustatory cortex, which was temporally restricted, coupled to the learning of a novel, but not familiar, taste and controlled by ERK. Using temporally and spatially restricted RNA interference knockdown of PSD-95 in vivo, we found that PSD-95 induction is necessary for learning novel tastes, but not for the recollection of familiar ones.

Original language	English
Pages (from-to)	1149-1151
Number of pages	3
Journal	Nature Neuroscience
Volume	11
Issue number	10
DOIs	https://doi.org/10.1038/nn.2190
State	Published - Oct 2008

Bibliographical note

Funding Information:
We thank G. Hannon (Cold Spring Harbor Laboratory) and P. Osten (Northwestern University, USA) for providing DNA vectors. We are grateful for the generous support of R. Malinow (Cold Spring Harbor Laboratory) and A. Lüthi (Friedrich Miescher Institute), in whose laboratories the lentiviruses were produced and characterized. We wish to thank A. Fine for constructive comments on the manuscript. This research was supported by the Israel Science Ffoundation and a Gene Memory Research Training Network EU grant to K.R.

ASJC Scopus subject areas

Neuroscience (all)

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title = "ERK-dependent PSD-95 induction in the gustatory cortex is necessary for taste learning, but not retrieval",

abstract = "The processes underlying long-term memory formation in the neocortex are poorly understood. Using taste learning, we found learning-related induction of PSD-95 in the gustatory cortex, which was temporally restricted, coupled to the learning of a novel, but not familiar, taste and controlled by ERK. Using temporally and spatially restricted RNA interference knockdown of PSD-95 in vivo, we found that PSD-95 induction is necessary for learning novel tastes, but not for the recollection of familiar ones.",

author = "Alina Elkobi and Ingrid Ehrlich and Katya Belelovsky and Liza Barki-Harrington and Kobi Rosenblum",

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AU - Barki-Harrington, Liza

AU - Rosenblum, Kobi

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ERK-dependent PSD-95 induction in the gustatory cortex is necessary for taste learning, but not retrieval

Abstract

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