Epigenetics and Pregnancy: Conditional Snapshot or Rolling Event

Mariana Andrawus, Lital Sharvit, Gil Atzmon

Research output: Contribution to journalReview articlepeer-review

Abstract

Epigenetics modification such as DNA methylation can affect maternal health during the gestation period. Furthermore, pregnancy can drive a range of physiological and molecular changes that have the potential to contribute to pathological conditions. Pregnancy-related risk factors include multiple environmental, behavioral, and hereditary factors that can impact maternal DNA methylation with long-lasting consequences. Identification of the epigenetic patterns linked to poor pregnancy outcomes is crucial since changes in DNA methylation patterns can have long-term effects. In this review, we provide an overview of the epigenetic changes that influence pregnancy-related molecular programming such as gestational diabetes, immune response, and pre-eclampsia, in an effort to close the gap in current understanding regarding interactions between the environment, the genetics of the fetus, and the pregnant woman.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume23
Issue number20
DOIs
StatePublished - 21 Oct 2022

Keywords

  • DNA methylation
  • epigenetics modification
  • inheritance
  • maternal stress
  • pre-eclampsia
  • pregnancy

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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