Abstract
Abstract: The phenomenon of paramutation describes the interaction between two alleles, in which one allele initiates inherited epigenetic conversion of another allele without affecting the DNA sequence. Epigenetic transformations due to paramutation are accompanied by the change in DNA and/or histone methylation patterns, affecting gene expression. Studies of paramutation in plants and animals have identified small non-coding RNAs as the main effector molecules required for the initiation of epigenetic changes in gene loci. Due to the fact that small non-coding RNAs can be transmitted across generations, the paramutation effect can be inherited and maintained in a population. In this review, we will systematically analyze examples of paramutation in different living systems described so far, highlighting common and different molecular and genetic aspects of paramutation between organisms, and considering the role of this phenomenon in evolution.
| Original language | English |
|---|---|
| Pages (from-to) | 1429-1450 |
| Number of pages | 22 |
| Journal | Biochemistry (Moscow) |
| Volume | 89 |
| Issue number | 8 |
| State | Published - Aug 2024 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© Pleiades Publishing, Ltd. 2024.
Keywords
- chromatin
- epigenetics
- gene expression
- non-Mendelian inheritance
- small non-coding RNAs
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
- Geriatrics and Gerontology