Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants

Yael Korem Kohanim; Avichai Tendler; Avi Mayo; Nir Friedman; Uri Alon

doi:10.1016/j.immuni.2020.04.022

Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants

Yael Korem Kohanim, Avichai Tendler, Avi Mayo, Nir Friedman, Uri Alon

Research output: Contribution to journal › Article › peer-review

Abstract

Some endocrine tissues are prone to autoimmune disease, whereas others are not. Korem Kohanim et al. propose the existence of an immune surveillance mechanism wherein auto-reactive T cells remove aberrant hyperproliferating and hypersecreting endocrine cells to prevent disruption of homeostasis. Autoimmunity is the cost of this surveillance mechanism.

Original language	English
Pages (from-to)	872-884.e5
Journal	Immunity
Volume	52
Issue number	5
DOIs	https://doi.org/10.1016/j.immuni.2020.04.022
State	Published - 19 May 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 The Authors

Keywords

Hashimoto's thyroiditis
autoimmune disease
circuit motif
hyperparathyroidism
hypersecreting adenoma
immune surveillance
primary biliary cirrhosis
systems biology
type 1 diabetes
vitiligo

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.immuni.2020.04.022

Cite this

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title = "Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants",

abstract = "Some endocrine tissues are prone to autoimmune disease, whereas others are not. Korem Kohanim et al. propose the existence of an immune surveillance mechanism wherein auto-reactive T cells remove aberrant hyperproliferating and hypersecreting endocrine cells to prevent disruption of homeostasis. Autoimmunity is the cost of this surveillance mechanism.",

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AU - Korem Kohanim, Yael

AU - Tendler, Avichai

AU - Mayo, Avi

AU - Friedman, Nir

AU - Alon, Uri

PY - 2020/5/19

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N2 - Some endocrine tissues are prone to autoimmune disease, whereas others are not. Korem Kohanim et al. propose the existence of an immune surveillance mechanism wherein auto-reactive T cells remove aberrant hyperproliferating and hypersecreting endocrine cells to prevent disruption of homeostasis. Autoimmunity is the cost of this surveillance mechanism.

AB - Some endocrine tissues are prone to autoimmune disease, whereas others are not. Korem Kohanim et al. propose the existence of an immune surveillance mechanism wherein auto-reactive T cells remove aberrant hyperproliferating and hypersecreting endocrine cells to prevent disruption of homeostasis. Autoimmunity is the cost of this surveillance mechanism.

KW - Hashimoto's thyroiditis

KW - autoimmune disease

KW - circuit motif

KW - hyperparathyroidism

KW - hypersecreting adenoma

KW - immune surveillance

KW - primary biliary cirrhosis

KW - systems biology

KW - type 1 diabetes

KW - vitiligo

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ER -

Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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