Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits

Karen Lavi; Gilad A. Jacobson; Kobi Rosenblum; Andreas Lüthi

doi:10.1016/j.celrep.2018.06.053

Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits

Karen Lavi, Gilad A. Jacobson, Kobi Rosenblum, Andreas Lüthi

Department of Neurobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Lavi et al. show that association of palatable tastant with malaise preferentially recruits gustatory cortex neurons projecting to the basolateral amygdala and shifts the representation of the conditioned tastant to become more similar to the representation of an intrinsically aversive tastant.

Original language	English
Pages (from-to)	278-283
Number of pages	6
Journal	Cell Reports
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2018.06.053
State	Published - 10 Jul 2018

Bibliographical note

Funding Information:
We thank J.P. Fadok and P. Tovote for comments on the manuscript and all members of the A.L. group for insightful comments on the work. We would like to thank C. Mueller, T.J. Lu, K. Bylund, A. Kovacevic, and the FMI core facilities for excellent technical assistance. This work was supported by the Novartis Research Foundation , the European Research Council (ERC ) under the European Union’s Horizon 2020 Research and Innovation Programme (Grant Agreement 669582 ), the National Center of Competences in Research : “SYNAPSY—The Synaptic Bases of Mental Diseases” (financed by the Swiss National Science Foundation ), and SNSF core grant (to A.L.), and by Israel Science Foundation (ISF) Grant 946/17 , ISF-Canada Grant 2395/15 , ISF Legacy Heritage Grant 604/15 , and ChromISyn—ERANET Grant 3-12492 (financed by Israel Ministry of Health ) (to K.R.).

Funding Information:
We thank J.P. Fadok and P. Tovote for comments on the manuscript and all members of the A.L. group for insightful comments on the work. We would like to thank C. Mueller, T.J. Lu, K. Bylund, A. Kovacevic, and the FMI core facilities for excellent technical assistance. This work was supported by the Novartis Research Foundation, the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Programme (Grant Agreement 669582), the National Center of Competences in Research: ?SYNAPSY?The Synaptic Bases of Mental Diseases? (financed by the Swiss National Science Foundation), and SNSF core grant (to A.L.), and by Israel Science Foundation (ISF) Grant 946/17, ISF-Canada Grant 2395/15, ISF Legacy Heritage Grant 604/15, and ChromISyn?ERANET Grant 3-12492 (financed by Israel Ministry of Health) (to K.R.).

Funding Information:
We thank J.P. Fadok and P. Tovote for comments on the manuscript and all members of the A.L. group for insightful comments on the work. We would like to thank C. Mueller, T.J. Lu, K. Bylund, A. Kovacevic, and the FMI core facilities for excellent technical assistance. This work was supported by the Novartis Research Foundation, the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Programme (Grant Agreement 669582), the National Center of Competences in Research: “SYNAPSY—The Synaptic Bases of Mental Diseases” (financed by the Swiss National Science Foundation), and SNSF core grant (to A.L.), and by Israel Science Foundation (ISF) Grant 946/17, ISF-Canada Grant 2395/15, ISF Legacy Heritage Grant 604/15, and ChromISyn—ERANET Grant 3-12492 (financed by Israel Ministry of Health) (to K.R.).

Keywords

BLA
CTA
associative learning
calcium imaging
conditioning
gustatory cortex

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2018.06.053

Cite this

@article{94c6049194894069a7a19780c88be3fa,

title = "Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits",

abstract = "Lavi et al. show that association of palatable tastant with malaise preferentially recruits gustatory cortex neurons projecting to the basolateral amygdala and shifts the representation of the conditioned tastant to become more similar to the representation of an intrinsically aversive tastant.",

keywords = "BLA, CTA, associative learning, calcium imaging, conditioning, gustatory cortex",

author = "Karen Lavi and Jacobson, {Gilad A.} and Kobi Rosenblum and Andreas L{\"u}thi",

note = "Funding Information: We thank J.P. Fadok and P. Tovote for comments on the manuscript and all members of the A.L. group for insightful comments on the work. We would like to thank C. Mueller, T.J. Lu, K. Bylund, A. Kovacevic, and the FMI core facilities for excellent technical assistance. This work was supported by the Novartis Research Foundation , the European Research Council (ERC ) under the European Union{\textquoteright}s Horizon 2020 Research and Innovation Programme (Grant Agreement 669582 ), the National Center of Competences in Research : “SYNAPSY—The Synaptic Bases of Mental Diseases” (financed by the Swiss National Science Foundation ), and SNSF core grant (to A.L.), and by Israel Science Foundation (ISF) Grant 946/17 , ISF-Canada Grant 2395/15 , ISF Legacy Heritage Grant 604/15 , and ChromISyn—ERANET Grant 3-12492 (financed by Israel Ministry of Health ) (to K.R.). Funding Information: We thank J.P. Fadok and P. Tovote for comments on the manuscript and all members of the A.L. group for insightful comments on the work. We would like to thank C. Mueller, T.J. Lu, K. Bylund, A. Kovacevic, and the FMI core facilities for excellent technical assistance. This work was supported by the Novartis Research Foundation, the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Programme (Grant Agreement 669582), the National Center of Competences in Research: ?SYNAPSY?The Synaptic Bases of Mental Diseases? (financed by the Swiss National Science Foundation), and SNSF core grant (to A.L.), and by Israel Science Foundation (ISF) Grant 946/17, ISF-Canada Grant 2395/15, ISF Legacy Heritage Grant 604/15, and ChromISyn?ERANET Grant 3-12492 (financed by Israel Ministry of Health) (to K.R.). Funding Information: We thank J.P. Fadok and P. Tovote for comments on the manuscript and all members of the A.L. group for insightful comments on the work. We would like to thank C. Mueller, T.J. Lu, K. Bylund, A. Kovacevic, and the FMI core facilities for excellent technical assistance. This work was supported by the Novartis Research Foundation, the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Programme (Grant Agreement 669582), the National Center of Competences in Research: “SYNAPSY—The Synaptic Bases of Mental Diseases” (financed by the Swiss National Science Foundation), and SNSF core grant (to A.L.), and by Israel Science Foundation (ISF) Grant 946/17, ISF-Canada Grant 2395/15, ISF Legacy Heritage Grant 604/15, and ChromISyn—ERANET Grant 3-12492 (financed by Israel Ministry of Health) (to K.R.).",

year = "2018",

month = jul,

day = "10",

doi = "10.1016/j.celrep.2018.06.053",

language = "English",

volume = "24",

pages = "278--283",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits

AU - Lavi, Karen

AU - Jacobson, Gilad A.

AU - Rosenblum, Kobi

AU - Lüthi, Andreas

N1 - Funding Information: We thank J.P. Fadok and P. Tovote for comments on the manuscript and all members of the A.L. group for insightful comments on the work. We would like to thank C. Mueller, T.J. Lu, K. Bylund, A. Kovacevic, and the FMI core facilities for excellent technical assistance. This work was supported by the Novartis Research Foundation , the European Research Council (ERC ) under the European Union’s Horizon 2020 Research and Innovation Programme (Grant Agreement 669582 ), the National Center of Competences in Research : “SYNAPSY—The Synaptic Bases of Mental Diseases” (financed by the Swiss National Science Foundation ), and SNSF core grant (to A.L.), and by Israel Science Foundation (ISF) Grant 946/17 , ISF-Canada Grant 2395/15 , ISF Legacy Heritage Grant 604/15 , and ChromISyn—ERANET Grant 3-12492 (financed by Israel Ministry of Health ) (to K.R.). Funding Information: We thank J.P. Fadok and P. Tovote for comments on the manuscript and all members of the A.L. group for insightful comments on the work. We would like to thank C. Mueller, T.J. Lu, K. Bylund, A. Kovacevic, and the FMI core facilities for excellent technical assistance. This work was supported by the Novartis Research Foundation, the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Programme (Grant Agreement 669582), the National Center of Competences in Research: ?SYNAPSY?The Synaptic Bases of Mental Diseases? (financed by the Swiss National Science Foundation), and SNSF core grant (to A.L.), and by Israel Science Foundation (ISF) Grant 946/17, ISF-Canada Grant 2395/15, ISF Legacy Heritage Grant 604/15, and ChromISyn?ERANET Grant 3-12492 (financed by Israel Ministry of Health) (to K.R.). Funding Information: We thank J.P. Fadok and P. Tovote for comments on the manuscript and all members of the A.L. group for insightful comments on the work. We would like to thank C. Mueller, T.J. Lu, K. Bylund, A. Kovacevic, and the FMI core facilities for excellent technical assistance. This work was supported by the Novartis Research Foundation, the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Programme (Grant Agreement 669582), the National Center of Competences in Research: “SYNAPSY—The Synaptic Bases of Mental Diseases” (financed by the Swiss National Science Foundation), and SNSF core grant (to A.L.), and by Israel Science Foundation (ISF) Grant 946/17, ISF-Canada Grant 2395/15, ISF Legacy Heritage Grant 604/15, and ChromISyn—ERANET Grant 3-12492 (financed by Israel Ministry of Health) (to K.R.).

PY - 2018/7/10

Y1 - 2018/7/10

N2 - Lavi et al. show that association of palatable tastant with malaise preferentially recruits gustatory cortex neurons projecting to the basolateral amygdala and shifts the representation of the conditioned tastant to become more similar to the representation of an intrinsically aversive tastant.

AB - Lavi et al. show that association of palatable tastant with malaise preferentially recruits gustatory cortex neurons projecting to the basolateral amygdala and shifts the representation of the conditioned tastant to become more similar to the representation of an intrinsically aversive tastant.

KW - BLA

KW - CTA

KW - associative learning

KW - calcium imaging

KW - conditioning

KW - gustatory cortex

UR - http://www.scopus.com/inward/record.url?scp=85049325730&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2018.06.053

DO - 10.1016/j.celrep.2018.06.053

M3 - Article

C2 - 29996089

AN - SCOPUS:85049325730

SN - 2211-1247

VL - 24

SP - 278

EP - 283

JO - Cell Reports

JF - Cell Reports

IS - 2

ER -

Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this