EMT and stemness in tumor dormancy and outgrowth: Are they intertwined processes?

Research output: Contribution to journalReview articlepeer-review


Metastases are the major cause of cancer patients' mortality and can occur years and even decades following apparently successful treatment of the primary tumor. Early dissemination of cancer cells, followed by a protracted period of dormancy at distant sites, has been recently recognized as the clinical explanation for this very-long latency. The mechanisms that govern tumor dormancy at distant sites and their reactivation to proliferating metastases are just beginning to be unraveled. Tumor cells, that survive the immune surveillance and hemodynamic forces along their journey in the circulation and successfully colonize and adopt to the new and "hostile" microenvironment and survive in a quiescent dormant state for years before emerging to proliferative state, must display high plasticity. Here we will discuss whether the plasticity of dormant tumor cells is required for their long-term survival and outgrowth. Specifically, we will focus on whether epithelial mesenchymal transition and acquisition of stem-like properties can dictate their quiescent and or their proliferative fate. Deeper understanding of these intertwining processes may facilitate in the future the development of novel therapies.

Original languageEnglish
Article number381
JournalFrontiers in Oncology
Issue numberSEP
StatePublished - 12 Sep 2018

Bibliographical note

Publisher Copyright:
© 2007 - 2018 Frontiers Media S.A. All Rights Reserved.


  • Cancer recurrence
  • Cancer stem cells
  • Disseminated tumor cells
  • Epithelial mesenchymal transition
  • Mesenchymal epithelial transition
  • Metastasis
  • Stemness
  • Tumor dormancy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'EMT and stemness in tumor dormancy and outgrowth: Are they intertwined processes?'. Together they form a unique fingerprint.

Cite this