Electron microscopic study of Bitot's spots

E. Meyer, B. Miller, S. Zonis

Research output: Contribution to journalArticlepeer-review


The histological and structural features of Bitot's spots are described. Light microscopy revealed squamous metaplasia with keratinization. Electron microscopy showed severe loss and attenuation in height of microvilli as well as widening of the intercellular spaces. The amorphous material overlying the conjunctiva was composed of cellular debris containing edemetous endoplasmic reticular membranes and lysozomes.

Original languageEnglish
Pages (from-to)42-44
Number of pages3
JournalMetabolic, Pediatric and Systemic Ophthalmology
Issue number2
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Ophthalmology


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