TY - JOUR
T1 - Efficacy of suppository analgesia in postabortion pain reduction
AU - Lowenstein, Lior
AU - Granot, Michal
AU - Tamir, Ada
AU - Glik, Aldo
AU - Deutsch, Michael
AU - Jakobi, Peter
AU - Zimmer, Etan Z.
PY - 2006/10
Y1 - 2006/10
N2 - Purpose: Termination of pregnancy is a painful procedure. Currently, there are no sufficient data regarding the best mode to reduce this pain. The aim of the study was to evaluate postabortion pain levels and to examine the analgesic effect of three different generic types of suppositories provided at the end of the surgical procedure prior to awakening from general anesthesia. Method: Two hundred seventeen women were randomly assigned to four groups: indomethacin (100 mg), paracetamol (1000 mg), tramadol (100 mg), and control group with no suppository treatment. Pain levels were evaluated by VAS five times - 15, 30, 60, 90 and 120 min after abortion. The number of doses of rescue analgesia with dipyrone (1 g po) was recorded. Results: There was a significant difference in pain levels between the four groups during the 2-h study (p<.05). Indomethacin always had the lowest VAS rank. Rescue analgesia was requested by 22/55 women in the control group, 10/55 in the tramadol group, 7/54 in the paracetamol group and 5/53 in the indomethacin group (χ2=19.0, p<.0001). Conclusion: The application of a single suppository of an analgesic drug, especially indomethacin, is a simple, inexpensive and safe mode to reduce postabortion pain.
AB - Purpose: Termination of pregnancy is a painful procedure. Currently, there are no sufficient data regarding the best mode to reduce this pain. The aim of the study was to evaluate postabortion pain levels and to examine the analgesic effect of three different generic types of suppositories provided at the end of the surgical procedure prior to awakening from general anesthesia. Method: Two hundred seventeen women were randomly assigned to four groups: indomethacin (100 mg), paracetamol (1000 mg), tramadol (100 mg), and control group with no suppository treatment. Pain levels were evaluated by VAS five times - 15, 30, 60, 90 and 120 min after abortion. The number of doses of rescue analgesia with dipyrone (1 g po) was recorded. Results: There was a significant difference in pain levels between the four groups during the 2-h study (p<.05). Indomethacin always had the lowest VAS rank. Rescue analgesia was requested by 22/55 women in the control group, 10/55 in the tramadol group, 7/54 in the paracetamol group and 5/53 in the indomethacin group (χ2=19.0, p<.0001). Conclusion: The application of a single suppository of an analgesic drug, especially indomethacin, is a simple, inexpensive and safe mode to reduce postabortion pain.
KW - Abortion
KW - Analgesia
KW - Pain
KW - Suppository
KW - Visual analogue scale
UR - http://www.scopus.com/inward/record.url?scp=33748680981&partnerID=8YFLogxK
U2 - 10.1016/j.contraception.2006.03.020
DO - 10.1016/j.contraception.2006.03.020
M3 - Article
C2 - 16982237
AN - SCOPUS:33748680981
SN - 0010-7824
VL - 74
SP - 345
EP - 348
JO - Contraception
JF - Contraception
IS - 4
ER -