Effects of non-weight bearing and hyperbaric oxygen therapy in vascular deprivation-induced osteonecrosis of the rat femoral head

B. Peskin; A. Shupak; D. Levin; D. Norman; Z. Jacob; J. H. Boss; I. Misselevich; D. N. Reis; C. Zinman

Effects of non-weight bearing and hyperbaric oxygen therapy in vascular deprivation-induced osteonecrosis of the rat femoral head

B. Peskin, A. Shupak, D. Levin, D. Norman, Z. Jacob, J. H. Boss, I. Misselevich, D. N. Reis, C. Zinman

Department of Communication Sciences and Disorders

Research output: Contribution to journal › Article › peer-review

Abstract

We examined the role of hyperbaric oxygenation (HBO₂) combined with non-weight bearing (NWB) in the treatment of vascular deprivation-induced osteonecrosis of the femoral head in the rat. Group 1 included 16 rats treated by a combination ofNWB and HBO₂. Twenty animals treated by NWB alone (group 2), and 18 rats which received no treatment (group 3), served as the control groups. Maximal benefit of HBO₂ was observed on Day 30 of the study. The femoral heads were less deformed in group 1 animals (P = 0.07). Preservation of the femoral heads was observed in a larger proportion of the HBO₂-treated animals (P = 0.06). A smaller proportion of high-grade new bone formation was observed, and more animals demonstrated well-regenerated hematopoietic tissue (P=0.08). The tendency for less deformation of the femoral head in the HBO₂-treated group might be a predictor of better function of the hip joint.

Original language	English
Pages (from-to)	187-194
Number of pages	8
Journal	Undersea and Hyperbaric Medicine
Volume	28
Issue number	4
State	Published - Sep 2001

Keywords

Femoral head
Hyperbaric oxygen
Non-weight bearing
Osteonecrosis
Rat

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Physiology (medical)

Cite this

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title = "Effects of non-weight bearing and hyperbaric oxygen therapy in vascular deprivation-induced osteonecrosis of the rat femoral head",

abstract = "We examined the role of hyperbaric oxygenation (HBO2) combined with non-weight bearing (NWB) in the treatment of vascular deprivation-induced osteonecrosis of the femoral head in the rat. Group 1 included 16 rats treated by a combination ofNWB and HBO2. Twenty animals treated by NWB alone (group 2), and 18 rats which received no treatment (group 3), served as the control groups. Maximal benefit of HBO2 was observed on Day 30 of the study. The femoral heads were less deformed in group 1 animals (P = 0.07). Preservation of the femoral heads was observed in a larger proportion of the HBO2-treated animals (P = 0.06). A smaller proportion of high-grade new bone formation was observed, and more animals demonstrated well-regenerated hematopoietic tissue (P=0.08). The tendency for less deformation of the femoral head in the HBO2-treated group might be a predictor of better function of the hip joint.",

keywords = "Femoral head, Hyperbaric oxygen, Non-weight bearing, Osteonecrosis, Rat",

author = "B. Peskin and A. Shupak and D. Levin and D. Norman and Z. Jacob and Boss, {J. H.} and I. Misselevich and Reis, {D. N.} and C. Zinman",

year = "2001",

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language = "English",

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pages = "187--194",

journal = "Undersea and Hyperbaric Medicine",

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T1 - Effects of non-weight bearing and hyperbaric oxygen therapy in vascular deprivation-induced osteonecrosis of the rat femoral head

AU - Peskin, B.

AU - Shupak, A.

AU - Levin, D.

AU - Norman, D.

AU - Jacob, Z.

AU - Boss, J. H.

AU - Misselevich, I.

AU - Reis, D. N.

AU - Zinman, C.

PY - 2001/9

Y1 - 2001/9

N2 - We examined the role of hyperbaric oxygenation (HBO2) combined with non-weight bearing (NWB) in the treatment of vascular deprivation-induced osteonecrosis of the femoral head in the rat. Group 1 included 16 rats treated by a combination ofNWB and HBO2. Twenty animals treated by NWB alone (group 2), and 18 rats which received no treatment (group 3), served as the control groups. Maximal benefit of HBO2 was observed on Day 30 of the study. The femoral heads were less deformed in group 1 animals (P = 0.07). Preservation of the femoral heads was observed in a larger proportion of the HBO2-treated animals (P = 0.06). A smaller proportion of high-grade new bone formation was observed, and more animals demonstrated well-regenerated hematopoietic tissue (P=0.08). The tendency for less deformation of the femoral head in the HBO2-treated group might be a predictor of better function of the hip joint.

AB - We examined the role of hyperbaric oxygenation (HBO2) combined with non-weight bearing (NWB) in the treatment of vascular deprivation-induced osteonecrosis of the femoral head in the rat. Group 1 included 16 rats treated by a combination ofNWB and HBO2. Twenty animals treated by NWB alone (group 2), and 18 rats which received no treatment (group 3), served as the control groups. Maximal benefit of HBO2 was observed on Day 30 of the study. The femoral heads were less deformed in group 1 animals (P = 0.07). Preservation of the femoral heads was observed in a larger proportion of the HBO2-treated animals (P = 0.06). A smaller proportion of high-grade new bone formation was observed, and more animals demonstrated well-regenerated hematopoietic tissue (P=0.08). The tendency for less deformation of the femoral head in the HBO2-treated group might be a predictor of better function of the hip joint.

KW - Femoral head

KW - Hyperbaric oxygen

KW - Non-weight bearing

KW - Osteonecrosis

KW - Rat

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M3 - Article

C2 - 12153146

AN - SCOPUS:0035453195

SN - 1066-2936

VL - 28

SP - 187

EP - 194

JO - Undersea and Hyperbaric Medicine

JF - Undersea and Hyperbaric Medicine

IS - 4

ER -

Effects of non-weight bearing and hyperbaric oxygen therapy in vascular deprivation-induced osteonecrosis of the rat femoral head

Abstract

Keywords

ASJC Scopus subject areas

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