Effects of melatonin on heat production and enzymatic activity in diurnal and in nocturnal rodents

A. Haim, F. Le

Research output: Contribution to journalArticlepeer-review


1. 1. Heat production by means of oxygen consumption (.Vo2), and enzymatic activity of malate dehydrogenase (MDH), lactate dehydrogenase (LDH), and glucose-6-phosphate dehydrogenase (G6PDH) were studied in diurnal (Rhabdomys pumilio) as well as nocturnal (Praomys natalensis) murids, as a response to melatonin treatment. 2. 2. A significant (P < 0.001) increase in .VO2 was noticed in melatonin treated mice of both species at ambient temperatures of Ta = 6°C, 25°C, 30°C, 32°C and 34°C, when compared to sham operated mice. A significant (P < 0.001) increase was also recorded in body temperature (Tb) at Ta = 6°C and 25°C. 3. 3. Enzymatic activity was significantly higher: P < 0.01 for MDH and LDH in R. pumilio, P < 0.05 for LDH, and P < 0.01 for MDH in P. natalensis, after melatonin administration when compared to sham operated animals.

Original languageEnglish
Pages (from-to)473-475
Number of pages3
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Issue number3
StatePublished - 1982
Externally publishedYes

Bibliographical note

Funding Information:
Acknow/edgrments~-We thankD r. N. Fairall and Prof. J. A. J. Nel for their helpful remarks on this manuscript. We are also grateful for the technical assistance provided by MessrsD. . Carr and A. Seabrook. This research was financially supported by the C.S.I.R. and the Mammal Research Institute, University of Pretoria. In this respect we would like to express our appreciation to Prof. J. D. Skinner.

ASJC Scopus subject areas

  • Physiology


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