Effects of ingested fruiting bodies, submerged culture biomass, and acidic polysaccharide glucuronoxylomannan of Tremella mesenterica Retz.:Fr. on glycemic responses in normal and diabetic rats

Hui Chen Lo; Fu Ann Tsai; Solomon P. Wasser; Jyuer Ger Yang; Bu Miin Huang

doi:10.1016/j.lfs.2005.08.033

Effects of ingested fruiting bodies, submerged culture biomass, and acidic polysaccharide glucuronoxylomannan of Tremella mesenterica Retz.:Fr. on glycemic responses in normal and diabetic rats

Hui Chen Lo, Fu Ann Tsai, Solomon P. Wasser, Jyuer Ger Yang, Bu Miin Huang

Department of Evolutionary and Environmental Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Mushroom polysaccharides have been shown to regulate glucose metabolism. Using male Wistar rats injected with saline (normal rats), streptozotocin (STZ - NT rats), or streptozotocin plus nicotinamide (STZ + NT rats), we investigated the hypoglycemic activity of orally ingested fruiting bodies (FB), submerged culture biomass (CM), or the acidic polysaccharide glucuronoxylomannan (GXM) of Tremella mesenterica, an edible jelly mushroom. Our results demonstrated that FB ingestion significantly attenuated the elevated blood glucose levels in an oral glucose tolerance test (OGTT) in STZ - NT rats. However, in STZ + NT rats, FB, CM, and GXM ingestion significantly attenuated the increases in food and water intake, 2-h postprandial blood glucose concentrations, and blood glucose levels in OGTT. Moreover, FB and GXM ingestion significantly decreased serum concentration of fructosamine in STZ + NT rats. Our results indicated that T. mesenterica might be developed as a potential oral hypoglycemic agent or functional food for diabetic patients and for persons with high risk for diabetes mellitus.

Original language	English
Pages (from-to)	1957-1966
Number of pages	10
Journal	Life Sciences
Volume	78
Issue number	17
DOIs	https://doi.org/10.1016/j.lfs.2005.08.033
State	Published - 20 Mar 2006

Bibliographical note

Funding Information:
This work was supported by the grant (CCH 4604) from Changhua Christian Hospital. We thank Ms. Su-Chen Lin and Ya-Chi Lai for their technical support.

Keywords

Fructosamine
Fruiting body
Glucuronoxylomannan
Hyperglycemia
Oral glucose tolerance test
Submerged culture biomass
Tremella mesenterica

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.lfs.2005.08.033

Cite this

@article{ef4fb18672ec46b09fab8a285a1701ef,

title = "Effects of ingested fruiting bodies, submerged culture biomass, and acidic polysaccharide glucuronoxylomannan of Tremella mesenterica Retz.:Fr. on glycemic responses in normal and diabetic rats",

abstract = "Mushroom polysaccharides have been shown to regulate glucose metabolism. Using male Wistar rats injected with saline (normal rats), streptozotocin (STZ - NT rats), or streptozotocin plus nicotinamide (STZ + NT rats), we investigated the hypoglycemic activity of orally ingested fruiting bodies (FB), submerged culture biomass (CM), or the acidic polysaccharide glucuronoxylomannan (GXM) of Tremella mesenterica, an edible jelly mushroom. Our results demonstrated that FB ingestion significantly attenuated the elevated blood glucose levels in an oral glucose tolerance test (OGTT) in STZ - NT rats. However, in STZ + NT rats, FB, CM, and GXM ingestion significantly attenuated the increases in food and water intake, 2-h postprandial blood glucose concentrations, and blood glucose levels in OGTT. Moreover, FB and GXM ingestion significantly decreased serum concentration of fructosamine in STZ + NT rats. Our results indicated that T. mesenterica might be developed as a potential oral hypoglycemic agent or functional food for diabetic patients and for persons with high risk for diabetes mellitus.",

keywords = "Fructosamine, Fruiting body, Glucuronoxylomannan, Hyperglycemia, Oral glucose tolerance test, Submerged culture biomass, Tremella mesenterica",

author = "Lo, {Hui Chen} and Tsai, {Fu Ann} and Wasser, {Solomon P.} and Yang, {Jyuer Ger} and Huang, {Bu Miin}",

note = "Funding Information: This work was supported by the grant (CCH 4604) from Changhua Christian Hospital. We thank Ms. Su-Chen Lin and Ya-Chi Lai for their technical support.",

year = "2006",

month = mar,

day = "20",

doi = "10.1016/j.lfs.2005.08.033",

language = "English",

volume = "78",

pages = "1957--1966",

journal = "Life Sciences",

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publisher = "Elsevier",

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}

Effects of ingested fruiting bodies, submerged culture biomass, and acidic polysaccharide glucuronoxylomannan of Tremella mesenterica Retz.:Fr. on glycemic responses in normal and diabetic rats. / Lo, Hui Chen; Tsai, Fu Ann; Wasser, Solomon P. et al.
In: Life Sciences, Vol. 78, No. 17, 20.03.2006, p. 1957-1966.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effects of ingested fruiting bodies, submerged culture biomass, and acidic polysaccharide glucuronoxylomannan of Tremella mesenterica Retz.:Fr. on glycemic responses in normal and diabetic rats

AU - Lo, Hui Chen

AU - Tsai, Fu Ann

AU - Wasser, Solomon P.

AU - Yang, Jyuer Ger

AU - Huang, Bu Miin

N1 - Funding Information: This work was supported by the grant (CCH 4604) from Changhua Christian Hospital. We thank Ms. Su-Chen Lin and Ya-Chi Lai for their technical support.

PY - 2006/3/20

Y1 - 2006/3/20

N2 - Mushroom polysaccharides have been shown to regulate glucose metabolism. Using male Wistar rats injected with saline (normal rats), streptozotocin (STZ - NT rats), or streptozotocin plus nicotinamide (STZ + NT rats), we investigated the hypoglycemic activity of orally ingested fruiting bodies (FB), submerged culture biomass (CM), or the acidic polysaccharide glucuronoxylomannan (GXM) of Tremella mesenterica, an edible jelly mushroom. Our results demonstrated that FB ingestion significantly attenuated the elevated blood glucose levels in an oral glucose tolerance test (OGTT) in STZ - NT rats. However, in STZ + NT rats, FB, CM, and GXM ingestion significantly attenuated the increases in food and water intake, 2-h postprandial blood glucose concentrations, and blood glucose levels in OGTT. Moreover, FB and GXM ingestion significantly decreased serum concentration of fructosamine in STZ + NT rats. Our results indicated that T. mesenterica might be developed as a potential oral hypoglycemic agent or functional food for diabetic patients and for persons with high risk for diabetes mellitus.

AB - Mushroom polysaccharides have been shown to regulate glucose metabolism. Using male Wistar rats injected with saline (normal rats), streptozotocin (STZ - NT rats), or streptozotocin plus nicotinamide (STZ + NT rats), we investigated the hypoglycemic activity of orally ingested fruiting bodies (FB), submerged culture biomass (CM), or the acidic polysaccharide glucuronoxylomannan (GXM) of Tremella mesenterica, an edible jelly mushroom. Our results demonstrated that FB ingestion significantly attenuated the elevated blood glucose levels in an oral glucose tolerance test (OGTT) in STZ - NT rats. However, in STZ + NT rats, FB, CM, and GXM ingestion significantly attenuated the increases in food and water intake, 2-h postprandial blood glucose concentrations, and blood glucose levels in OGTT. Moreover, FB and GXM ingestion significantly decreased serum concentration of fructosamine in STZ + NT rats. Our results indicated that T. mesenterica might be developed as a potential oral hypoglycemic agent or functional food for diabetic patients and for persons with high risk for diabetes mellitus.

KW - Fructosamine

KW - Fruiting body

KW - Glucuronoxylomannan

KW - Hyperglycemia

KW - Oral glucose tolerance test

KW - Submerged culture biomass

KW - Tremella mesenterica

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SN - 0024-3205

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JF - Life Sciences

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ER -

Effects of ingested fruiting bodies, submerged culture biomass, and acidic polysaccharide glucuronoxylomannan of Tremella mesenterica Retz.:Fr. on glycemic responses in normal and diabetic rats

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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