Effects of ingested fruiting bodies, submerged culture biomass, and acidic polysaccharide glucuronoxylomannan of Tremella mesenterica Retz.:Fr. on glycemic responses in normal and diabetic rats

Hui Chen Lo, Fu Ann Tsai, Solomon P. Wasser, Jyuer Ger Yang, Bu Miin Huang

Research output: Contribution to journalArticlepeer-review

Abstract

Mushroom polysaccharides have been shown to regulate glucose metabolism. Using male Wistar rats injected with saline (normal rats), streptozotocin (STZ - NT rats), or streptozotocin plus nicotinamide (STZ + NT rats), we investigated the hypoglycemic activity of orally ingested fruiting bodies (FB), submerged culture biomass (CM), or the acidic polysaccharide glucuronoxylomannan (GXM) of Tremella mesenterica, an edible jelly mushroom. Our results demonstrated that FB ingestion significantly attenuated the elevated blood glucose levels in an oral glucose tolerance test (OGTT) in STZ - NT rats. However, in STZ + NT rats, FB, CM, and GXM ingestion significantly attenuated the increases in food and water intake, 2-h postprandial blood glucose concentrations, and blood glucose levels in OGTT. Moreover, FB and GXM ingestion significantly decreased serum concentration of fructosamine in STZ + NT rats. Our results indicated that T. mesenterica might be developed as a potential oral hypoglycemic agent or functional food for diabetic patients and for persons with high risk for diabetes mellitus.

Original languageEnglish
Pages (from-to)1957-1966
Number of pages10
JournalLife Sciences
Volume78
Issue number17
DOIs
StatePublished - 20 Mar 2006

Bibliographical note

Funding Information:
This work was supported by the grant (CCH 4604) from Changhua Christian Hospital. We thank Ms. Su-Chen Lin and Ya-Chi Lai for their technical support.

Keywords

  • Fructosamine
  • Fruiting body
  • Glucuronoxylomannan
  • Hyperglycemia
  • Oral glucose tolerance test
  • Submerged culture biomass
  • Tremella mesenterica

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)
  • Pharmacology, Toxicology and Pharmaceutics (all)

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