Effects of caloric restriction and exercise training on skeletal muscle histochemistry in aging fischer 344 rats

David T. Lowenthal, Zebulon V. Kendrick, Joseph W. Starnes, Eli Carmeli

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to determine the effects of calorie restriction and exercise on hindlimb histochemistry and fiber type in Fischer 344 rats as they advanced from adulthood through senescence. At 10 months of age, animals were divided into sedentary fed ad libitum, exercise (18 m/min, 8% grade, 20 min/day, 5 days/week) fed ad libitum, and calorie restricted by alternate days of feeding. Succinic dehydrogenase, myosin adenosine triphosphatase (mATPase at pH 9.4), nicotine adenonine dinucleotide reductase, and Periodic Acid Shiff histochemical stains were performed on plantaris and soleus muscles. The results indicated that aging resulted in a progressive decline in plantaris Type I muscle fiber in sedentary animals, while exercise resulted in maintenance of these fibers. The percent of plantaris Type II fibers increased between 10 and 24 months of age. Exercise also resulted in a small, but significant, increase in the percentage of plantaris Type IIa fibers at 24 months of age. The soleus fiber distribution for Type I fibers was unaffected by increasing age in all groups of animals. The implications of these results suggest the implementation of exercise as a lifestyle modification as early as possible.

Original languageEnglish
Pages (from-to)1339-1349
Number of pages11
JournalThe Scientific World Journal
Volume6
DOIs
StatePublished - 13 Oct 2006
Externally publishedYes

Keywords

  • Aging
  • Caloric restriction
  • Running
  • Skeletal muscle

ASJC Scopus subject areas

  • General Environmental Science
  • General Biochemistry, Genetics and Molecular Biology

Fingerprint

Dive into the research topics of 'Effects of caloric restriction and exercise training on skeletal muscle histochemistry in aging fischer 344 rats'. Together they form a unique fingerprint.

Cite this