Effect of the recombinant human heat shock protein HSP70 on the biochemical properties of blood in a model of endotoxic shock in rats

V. F. Ostrov; G. A. Slashcheva; T. I. Zharmukhamedova; D. G. Garbuz; M. B. Evgen'ev; A. N. Murashev

Effect of the recombinant human heat shock protein HSP70 on the biochemical properties of blood in a model of endotoxic shock in rats

V. F. Ostrov, G. A. Slashcheva, T. I. Zharmukhamedova, D. G. Garbuz, M. B. Evgen'ev, A. N. Murashev

Institute of Evolution

Research output: Contribution to journal › Article › peer-review

Abstract

The protective effects of 70-kDa heat shock proteins (HSP70) were studied following the intravenous administration in rats with endotoxic shock. The antitoxic effects of both bovine HSP70 (bHSP70) and human recombinant HSP70 (hrHSP70) were compared. The preventive uptake of HSP70 decreased the toxic influence of the E. coll endotoxin on the rats' bodies and significantly increased the survival of the animals during the experiment.

Original language	English
Pages (from-to)	337-342
Number of pages	6
Journal	Bioorganicheskaia khimiia
Volume	36
Issue number	3
State	Published - May 2010

ASJC Scopus subject areas

General Medicine

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title = "Effect of the recombinant human heat shock protein HSP70 on the biochemical properties of blood in a model of endotoxic shock in rats",

abstract = "The protective effects of 70-kDa heat shock proteins (HSP70) were studied following the intravenous administration in rats with endotoxic shock. The antitoxic effects of both bovine HSP70 (bHSP70) and human recombinant HSP70 (hrHSP70) were compared. The preventive uptake of HSP70 decreased the toxic influence of the E. coll endotoxin on the rats' bodies and significantly increased the survival of the animals during the experiment.",

author = "Ostrov, {V. F.} and Slashcheva, {G. A.} and Zharmukhamedova, {T. I.} and Garbuz, {D. G.} and Evgen'ev, {M. B.} and Murashev, {A. N.}",

year = "2010",

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language = "English",

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pages = "337--342",

journal = "Bioorganicheskaia khimiia",

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T1 - Effect of the recombinant human heat shock protein HSP70 on the biochemical properties of blood in a model of endotoxic shock in rats

AU - Ostrov, V. F.

AU - Slashcheva, G. A.

AU - Zharmukhamedova, T. I.

AU - Garbuz, D. G.

AU - Evgen'ev, M. B.

AU - Murashev, A. N.

PY - 2010/5

Y1 - 2010/5

N2 - The protective effects of 70-kDa heat shock proteins (HSP70) were studied following the intravenous administration in rats with endotoxic shock. The antitoxic effects of both bovine HSP70 (bHSP70) and human recombinant HSP70 (hrHSP70) were compared. The preventive uptake of HSP70 decreased the toxic influence of the E. coll endotoxin on the rats' bodies and significantly increased the survival of the animals during the experiment.

AB - The protective effects of 70-kDa heat shock proteins (HSP70) were studied following the intravenous administration in rats with endotoxic shock. The antitoxic effects of both bovine HSP70 (bHSP70) and human recombinant HSP70 (hrHSP70) were compared. The preventive uptake of HSP70 decreased the toxic influence of the E. coll endotoxin on the rats' bodies and significantly increased the survival of the animals during the experiment.

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M3 - Article

C2 - 20644588

AN - SCOPUS:77955289620

SN - 0132-3423

VL - 36

SP - 337

EP - 342

JO - Bioorganicheskaia khimiia

JF - Bioorganicheskaia khimiia

IS - 3

ER -

Effect of the recombinant human heat shock protein HSP70 on the biochemical properties of blood in a model of endotoxic shock in rats

Abstract

ASJC Scopus subject areas

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