Effect of smoking on the clinical progression of HIV-1 infection

Noya Galai, Lawrence P. Park, Jerry Wesch, Barbara Visscher, Sharon Riddler, Joseph B. Margolick

Research output: Contribution to journalArticlepeer-review


Cigarette smoking as a risk factor in progression of HIV-1 disease was investigated in the Multicenter AIDS Cohort Study of homosexual men. Longitudinal data for T-cell subsets, HIV-related clinical symptoms, smoking behavior, and AIDS medication use were collected semiannually from 2,499 HIV- 1-seropositive men for up to 9 years. Survival methods, including Kaplan- Meier analysis and multivariate Cox regression models, were used to assess the effect of cigarette smoking on development of Pneumocystis carinii pneumonia (PCP), AIDS, death, and self-reported oral thrush. After adjustment for CD4+ lymphocyte count and use of antiretroviral and anti-PCP medications, smoking was not significantly associated with progression to PCP, AIDS, or death in either the HIV-seroprevalent or-seroincident cohort members. Among men who had baseline CD4+ cell counts >200/μl, smoking was associated with a 40% increase in the hazard of oral thrush (p ≤ 0.01). These data indicate that cigarette smoking does not have a major effect on the progression of HIV-1 infection to AIDS or death but may affect the incidence of oral thrush.

Original languageEnglish
Pages (from-to)451-458
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Issue number5
StatePublished - 15 Apr 1997
Externally publishedYes


  • AIDS
  • Cigarette smoking
  • HIV-1 disease progression
  • Oral thrush

ASJC Scopus subject areas

  • Virology
  • Immunology and Allergy
  • Immunology

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