Effect of hyperthermia on AKR lymphoma variants differing in degree of malignancy

Yehonatan Sharabi, Geula Klorin, Judith Leibovici

Research output: Contribution to journalArticlepeer-review


The effect of hyperthermic treatment on AKR lymphoma cells of varying malignancy was investigated. Tumor cells were pretreated at 37 or 43°C and then injected to mice. The effect on the highly malignant variant, TAU-38, was compared to that on the low-malignancy variant, TAU-39, following both subcutaneous (s.c.) and intravenous (i.v.) inoculation. Hyperthermia showed no effect on the TAU-39 variant following s.c. inoculation on the primary tumors or mice survival, but the TAU-38 variant exhibited a significant delay of tumor appearance following treatment, namely, decreased tumor size and increased life span. Following i.v. inoculation, in both variants, hyperthermia caused a significant decrease in metastatic spread and an increased life span. We conclude that hyperthermia, in addition to exerting a greater effect on the high-malignancy variant, acts at the late phases of metastasis. Hyperthermia might therefore have a place in the management of cancer in its advanced disseminated phase.

Original languageEnglish
Pages (from-to)791-798
Number of pages8
JournalCancer Investigation
Issue number8
StatePublished - 2001
Externally publishedYes


  • AKR lymphoma
  • Hyperthermia
  • Metastasis
  • Survival
  • Varying malignancy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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