Early transvaginal sonographic diagnosis of alobar holoprosencephaly

Moshe Bronshtein, Zeev Wiener

Research output: Contribution to journalArticlepeer-review


Holoprosencephaly is a cerebral anomaly resulting from incomplete cleavage of the primitive prosencephalon or forebrain. Early detection of this anomaly is very important since the most severe form is incompatible with life. The diagnosis also signals the need for a chromosomal determination since chromosomal abnormalities have been associated with this anomaly. An early diagnosis of alobar holoprosencephaly at 14 weeks' gestation, employing transvaginal sonography, is reported. Our findings are compared with prenatal transabdominal sonographic findings of holoprosencephaly which have been reported during the last decade in the literature.

Original languageEnglish
Pages (from-to)459-462
Number of pages4
JournalPrenatal Diagnosis
Issue number7
StatePublished - Jul 1991
Externally publishedYes


  • Holoprosencephaly
  • Prenatal diagnosis
  • Transvaginal sonography

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynecology


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