Early and late onset fetal microphthalmia

Shraga Blazer, Etan Z. Zimmer, Eedy Mezer, Moshe Bronshtein

Research output: Contribution to journalArticlepeer-review


Objective: The purpose of this study was to present sonographic and pathologic findings in early and late onset fetal microphthalmia. Study design: Fetal sonography was prospectively performed in 30,989 consecutive pregnancies at 14 to 24 weeks' gestation. In addition, we retrospectively reevaluated US recordings of 4 fetuses from other hospitals, in which normal eyes were observed in early and midgestation and microphthalmia was diagnosed only in the third trimester of pregnancy or after birth. Results: Microphthalmia was detected in 13 fetuses in the prospective group. Twelve of 13 had additional structural and chromosomal anomalies. Termination of pregnancy was performed in 12 cases. In the retrospective group of late onset microphthalmia we confirmed the normal eye measurements performed in the early and midpregnancy. Severe vision impairment or blindness was noted in 3 of these children, while the fourth pregnancy was terminated. Conclusion: Normal measurements of the fetal eyes in early and midpregnancy do not exclude the possibility of subsequent development of microphthalmia.

Original languageEnglish
Pages (from-to)1354-1359
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Issue number5
StatePublished - May 2006
Externally publishedYes


  • Fetus
  • Microphthalmia
  • Ultrasound

ASJC Scopus subject areas

  • Obstetrics and Gynecology


Dive into the research topics of 'Early and late onset fetal microphthalmia'. Together they form a unique fingerprint.

Cite this