Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning

Elena Musat; Erik Roelofs; Raquel Bar-Deroma; Paul Fenton; Akos Gulyban; Laurence Collette; Roger Stupp; Damien C. Weber; J. Bernard Davis; Edwin Aird; Brigitta G. Baumert

doi:10.1016/j.radonc.2010.03.005

Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning

Elena Musat
, Erik Roelofs
, Raquel Bar-Deroma
, Paul Fenton
, Akos Gulyban
, Laurence Collette
, Roger Stupp
, Damien C. Weber
, J. Bernard Davis
, Edwin Aird
, Brigitta G. Baumert

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas. Materials and methods: RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF× CF); dose homogeneity in PTV (U). Results: Forty-one RT plans were evaluated. Only two (5%) centres were requested to repeat CTV-PTV delineations. Three (7%) plans had a significant under-dosage and dose homogeneity in one deviated > 10%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTV_Dmin, improving CF. U correlated with PTV_Dmax. Conclusion: Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue.

Original language	English
Pages (from-to)	218-224
Number of pages	7
Journal	Radiotherapy and Oncology
Volume	95
Issue number	2
DOIs	https://doi.org/10.1016/j.radonc.2010.03.005
State	Published - May 2010
Externally published	Yes

Keywords

Conformal radiotherapy
Conformity indices
Dummy run
Homogeneity
Low-grade gliomas
Quality assurance

ASJC Scopus subject areas

Hematology
Oncology
Radiology Nuclear Medicine and imaging

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10.1016/j.radonc.2010.03.005

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Musat, E., Roelofs, E., Bar-Deroma, R., Fenton, P., Gulyban, A., Collette, L., Stupp, R., Weber, D. C., Davis, J. B., Aird, E., & Baumert, B. G. (2010). Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning. Radiotherapy and Oncology, 95(2), 218-224. https://doi.org/10.1016/j.radonc.2010.03.005

@article{2433b0c3536b4f7993e96e64ad26ada0,

title = "Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning",

abstract = "Purpose: Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas. Materials and methods: RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF× CF); dose homogeneity in PTV (U). Results: Forty-one RT plans were evaluated. Only two (5\%) centres were requested to repeat CTV-PTV delineations. Three (7\%) plans had a significant under-dosage and dose homogeneity in one deviated > 10\%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTVDmin, improving CF. U correlated with PTVDmax. Conclusion: Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue.",

keywords = "Conformal radiotherapy, Conformity indices, Dummy run, Homogeneity, Low-grade gliomas, Quality assurance",

author = "Elena Musat and Erik Roelofs and Raquel Bar-Deroma and Paul Fenton and Akos Gulyban and Laurence Collette and Roger Stupp and Weber, \{Damien C.\} and Davis, \{J. Bernard\} and Edwin Aird and Baumert, \{Brigitta G.\}",

year = "2010",

month = may,

doi = "10.1016/j.radonc.2010.03.005",

language = "English",

volume = "95",

pages = "218--224",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

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Musat, E, Roelofs, E, Bar-Deroma, R, Fenton, P, Gulyban, A, Collette, L, Stupp, R, Weber, DC, Davis, JB, Aird, E & Baumert, BG 2010, 'Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning', Radiotherapy and Oncology, vol. 95, no. 2, pp. 218-224. https://doi.org/10.1016/j.radonc.2010.03.005

TY - JOUR

T1 - Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033

T2 - First evaluation of quality of radiotherapy planning

AU - Musat, Elena

AU - Roelofs, Erik

AU - Bar-Deroma, Raquel

AU - Fenton, Paul

AU - Gulyban, Akos

AU - Collette, Laurence

AU - Stupp, Roger

AU - Weber, Damien C.

AU - Davis, J. Bernard

AU - Aird, Edwin

AU - Baumert, Brigitta G.

PY - 2010/5

Y1 - 2010/5

N2 - Purpose: Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas. Materials and methods: RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF× CF); dose homogeneity in PTV (U). Results: Forty-one RT plans were evaluated. Only two (5%) centres were requested to repeat CTV-PTV delineations. Three (7%) plans had a significant under-dosage and dose homogeneity in one deviated > 10%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTVDmin, improving CF. U correlated with PTVDmax. Conclusion: Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue.

AB - Purpose: Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas. Materials and methods: RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF× CF); dose homogeneity in PTV (U). Results: Forty-one RT plans were evaluated. Only two (5%) centres were requested to repeat CTV-PTV delineations. Three (7%) plans had a significant under-dosage and dose homogeneity in one deviated > 10%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTVDmin, improving CF. U correlated with PTVDmax. Conclusion: Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue.

KW - Conformal radiotherapy

KW - Conformity indices

KW - Dummy run

KW - Homogeneity

KW - Low-grade gliomas

KW - Quality assurance

UR - https://www.scopus.com/pages/publications/77956621835

U2 - 10.1016/j.radonc.2010.03.005

DO - 10.1016/j.radonc.2010.03.005

M3 - Article

C2 - 20378192

AN - SCOPUS:77956621835

SN - 0167-8140

VL - 95

SP - 218

EP - 224

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 2

ER -

Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning

Abstract

Keywords

ASJC Scopus subject areas

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