Dopamine asymmetries predict orienting bias in healthy individuals.

Rachel Tomer, Heleen A. Slagter, Bradley T. Christian, Andrew S. Fox, Carlye R. King, Dhanabalan Murali, Richard J. Davidson

Research output: Contribution to journalArticlepeer-review

Abstract

Pseudoneglect is traditionally viewed as reflecting right hemisphere specialization for processing spatial information, resulting in orienting toward the contralateral, left, hemispace. Recent evidence suggests that healthy individuals differ from each other in both direction and magnitude of orienting bias, and moreover, the bias displayed by a person is consistent across time, suggesting that it may represent a trait of the individual. Animal studies reveal consistent orienting bias within an individual, which reflects asymmetry in dopaminergic brain systems. We measured basal D2-like receptor binding using positron emission tomography and the high-affinity ligand [F-18]fallypride, to test the hypothesis that asymmetry in dopaminergic neurotransmission in healthy humans modulates the orienting bias in humans. As predicted, we found that individual differences in the direction and magnitude of the orienting bias were strongly associated with the pattern of asymmetric binding of dopamine (DA) D2 receptors in the striatum, as well as clusters in the frontal and temporal cortex. These findings show for the first time that orienting bias reflects individual differences in the lateralization of DA systems in the healthy human brain.

Original languageEnglish
Pages (from-to)2899-2904
Number of pages6
JournalCerebral Cortex
Volume23
Issue number12
DOIs
StatePublished - Dec 2013

Bibliographical note

Funding Information:
This work was supported by the National Institute of Mental Health (grant numbers MH43454 and P50-MH084051) and the Fetzer Institute to R.J.D. and core support from P30-HD003352 (M. Seltzer, PI).

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience

Fingerprint

Dive into the research topics of 'Dopamine asymmetries predict orienting bias in healthy individuals.'. Together they form a unique fingerprint.

Cite this