Does unilateral dopamine deficit contribute to depression?

Jacques Barber, Rachel Tomer, Hava Sroka, Michael S. Myslobodsky

Research output: Contribution to journalArticlepeer-review


A system of emotional control of behavior is believed to be lateralized to the right hemisphere. Given that dopaminergic pathways are involved in affective behavior, depression, which is recognized as an integral part of Parkinson's disease, may be associated with a dopamine imbalance. The present study examined this hypothesis in patients with unilateral symptomatology indicating either left hemisphere parkinsonism (LHP) or right hemisphere parkinsonism (RHP). Sixteen patients were tested on a battery of neuropsychological tests and several scales for evaluating mood. The two groups did not differ significantly on either cognitive or emotional measures. However, RHP patients rated themselves higher on the Present Scale of Cantril, and showed some neglect of the left visual field, as compared to LHP patients.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalPsychiatry Research
Issue number1
StatePublished - May 1985
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgments. The assistanceo f M. Mint] and Y. Glickson is gratefully acknowledged. This work was partially supported by a grant from the Israel Foundation Trustees (R. Tomer). and a gift from Mr. Ackerman (M.S. Myslobodsky).


  • depression
  • dopamine
  • Hemi-parkinsonism
  • laterality

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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