Does unilateral dopamine deficit contribute to depression?

Jacques Barber; Rachel Tomer; Hava Sroka; Michael S. Myslobodsky

doi:10.1016/0165-1781(85)90035-6

Does unilateral dopamine deficit contribute to depression?

Jacques Barber, Rachel Tomer, Hava Sroka, Michael S. Myslobodsky

Research output: Contribution to journal › Article › peer-review

Abstract

A system of emotional control of behavior is believed to be lateralized to the right hemisphere. Given that dopaminergic pathways are involved in affective behavior, depression, which is recognized as an integral part of Parkinson's disease, may be associated with a dopamine imbalance. The present study examined this hypothesis in patients with unilateral symptomatology indicating either left hemisphere parkinsonism (LHP) or right hemisphere parkinsonism (RHP). Sixteen patients were tested on a battery of neuropsychological tests and several scales for evaluating mood. The two groups did not differ significantly on either cognitive or emotional measures. However, RHP patients rated themselves higher on the Present Scale of Cantril, and showed some neglect of the left visual field, as compared to LHP patients.

Original language	English
Pages (from-to)	17-24
Number of pages	8
Journal	Psychiatry Research
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(85)90035-6
State	Published - May 1985
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgments. The assistanceo f M. Mint] and Y. Glickson is gratefully acknowledged. This work was partially supported by a grant from the Israel Foundation Trustees (R. Tomer). and a gift from Mr. Ackerman (M.S. Myslobodsky).

Keywords

Hemi-parkinsonism
depression
dopamine
laterality

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

Access to Document

10.1016/0165-1781(85)90035-6

Cite this

@article{90657d0fb8694607bd7790036578b69f,

title = "Does unilateral dopamine deficit contribute to depression?",

abstract = "A system of emotional control of behavior is believed to be lateralized to the right hemisphere. Given that dopaminergic pathways are involved in affective behavior, depression, which is recognized as an integral part of Parkinson's disease, may be associated with a dopamine imbalance. The present study examined this hypothesis in patients with unilateral symptomatology indicating either left hemisphere parkinsonism (LHP) or right hemisphere parkinsonism (RHP). Sixteen patients were tested on a battery of neuropsychological tests and several scales for evaluating mood. The two groups did not differ significantly on either cognitive or emotional measures. However, RHP patients rated themselves higher on the Present Scale of Cantril, and showed some neglect of the left visual field, as compared to LHP patients.",

keywords = "Hemi-parkinsonism, depression, dopamine, laterality",

author = "Jacques Barber and Rachel Tomer and Hava Sroka and Myslobodsky, {Michael S.}",

note = "Funding Information: Acknowledgments. The assistanceo f M. Mint] and Y. Glickson is gratefully acknowledged. This work was partially supported by a grant from the Israel Foundation Trustees (R. Tomer). and a gift from Mr. Ackerman (M.S. Myslobodsky).",

year = "1985",

month = may,

doi = "10.1016/0165-1781(85)90035-6",

language = "English",

volume = "15",

pages = "17--24",

journal = "Psychiatry Research",

issn = "0165-1781",