Diversity in the circulation of influenza a(H3n2) viruses in the northern hemisphere in the 2018–19 season

Rakefet Pando; Shahar Stern; Ital Nemet; Aharona Glatman-Freedman; Hanna Sefty; Neta S. Zuckerman; Yaron Drori; Nehemya Friedman; John W. McCauley; Lital Keinan-Boker; Ella Mendelson; Rodney S. Daniels; Michal Mandelboim

doi:10.3390/vaccines9040375

Diversity in the circulation of influenza a(H3n2) viruses in the northern hemisphere in the 2018–19 season

Rakefet Pando, Shahar Stern, Ital Nemet, Aharona Glatman-Freedman, Hanna Sefty, Neta S. Zuckerman, Yaron Drori, Nehemya Friedman, John W. McCauley, Lital Keinan-Boker, Ella Mendelson, Rodney S. Daniels, Michal Mandelboim

School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used nasopharyngeal samples collected from outpatient and hospitalized patients in Israel and data reported in ECDC, CDC, and WHO databases. Influenza A(H3N2) was dominant in Israel, while in Europe, Asia, and USA, A(H1N1)pdm09 virus circulated first, and then the A(H3N2) virus also appeared. Phylogenetic analysis indicated that A(H3N2) viruses circulating in Israel belonged to clade-3C.3a, while in Europe, Asia, and USA, A(H3N2) viruses belonged to subclade-3C.2a1, but were later replaced by clade-3C.3a viruses in USA. The vaccine A(H3N2) components of that year, A/Singapore/INFIMH-16-0019/2016-(H3N2)-like-viruses, belonged to clade-3C.2a1. The circulation of different influenza subtypes and clades of A(H3N2) viruses in a single season highlights the need for universal influenza vaccines.

Original language	English
Article number	375
Journal	Vaccines
Volume	9
Issue number	4
DOIs	https://doi.org/10.3390/vaccines9040375
State	Published - Apr 2021

Bibliographical note

Funding Information:
Funding: For the purpose of Open Access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. This work was supported in part by the Francis Crick Institute which receives its core funding from Cancer Research UK (FC001030), the UK Medical Research Council (FC001030), and the Wellcome Trust (FC001030).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Circulation
Clade
Influenza A
Vaccine

ASJC Scopus subject areas

Immunology
Pharmacology
Drug Discovery
Infectious Diseases
Pharmacology (medical)

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10.3390/vaccines9040375

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Pando, R., Stern, S., Nemet, I., Glatman-Freedman, A., Sefty, H., Zuckerman, N. S., Drori, Y., Friedman, N., McCauley, J. W., Keinan-Boker, L., Mendelson, E., Daniels, R. S., & Mandelboim, M. (2021). Diversity in the circulation of influenza a(H3n2) viruses in the northern hemisphere in the 2018–19 season. Vaccines, 9(4), [375]. https://doi.org/10.3390/vaccines9040375

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abstract = "While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used nasopharyngeal samples collected from outpatient and hospitalized patients in Israel and data reported in ECDC, CDC, and WHO databases. Influenza A(H3N2) was dominant in Israel, while in Europe, Asia, and USA, A(H1N1)pdm09 virus circulated first, and then the A(H3N2) virus also appeared. Phylogenetic analysis indicated that A(H3N2) viruses circulating in Israel belonged to clade-3C.3a, while in Europe, Asia, and USA, A(H3N2) viruses belonged to subclade-3C.2a1, but were later replaced by clade-3C.3a viruses in USA. The vaccine A(H3N2) components of that year, A/Singapore/INFIMH-16-0019/2016-(H3N2)-like-viruses, belonged to clade-3C.2a1. The circulation of different influenza subtypes and clades of A(H3N2) viruses in a single season highlights the need for universal influenza vaccines.",

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note = "Funding Information: Funding: For the purpose of Open Access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. This work was supported in part by the Francis Crick Institute which receives its core funding from Cancer Research UK (FC001030), the UK Medical Research Council (FC001030), and the Wellcome Trust (FC001030). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Pando, Rakefet

AU - Stern, Shahar

AU - Nemet, Ital

AU - Glatman-Freedman, Aharona

AU - Sefty, Hanna

AU - Zuckerman, Neta S.

AU - Drori, Yaron

AU - Friedman, Nehemya

AU - McCauley, John W.

AU - Keinan-Boker, Lital

AU - Mendelson, Ella

AU - Daniels, Rodney S.

AU - Mandelboim, Michal

N1 - Funding Information: Funding: For the purpose of Open Access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. This work was supported in part by the Francis Crick Institute which receives its core funding from Cancer Research UK (FC001030), the UK Medical Research Council (FC001030), and the Wellcome Trust (FC001030). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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N2 - While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used nasopharyngeal samples collected from outpatient and hospitalized patients in Israel and data reported in ECDC, CDC, and WHO databases. Influenza A(H3N2) was dominant in Israel, while in Europe, Asia, and USA, A(H1N1)pdm09 virus circulated first, and then the A(H3N2) virus also appeared. Phylogenetic analysis indicated that A(H3N2) viruses circulating in Israel belonged to clade-3C.3a, while in Europe, Asia, and USA, A(H3N2) viruses belonged to subclade-3C.2a1, but were later replaced by clade-3C.3a viruses in USA. The vaccine A(H3N2) components of that year, A/Singapore/INFIMH-16-0019/2016-(H3N2)-like-viruses, belonged to clade-3C.2a1. The circulation of different influenza subtypes and clades of A(H3N2) viruses in a single season highlights the need for universal influenza vaccines.

AB - While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used nasopharyngeal samples collected from outpatient and hospitalized patients in Israel and data reported in ECDC, CDC, and WHO databases. Influenza A(H3N2) was dominant in Israel, while in Europe, Asia, and USA, A(H1N1)pdm09 virus circulated first, and then the A(H3N2) virus also appeared. Phylogenetic analysis indicated that A(H3N2) viruses circulating in Israel belonged to clade-3C.3a, while in Europe, Asia, and USA, A(H3N2) viruses belonged to subclade-3C.2a1, but were later replaced by clade-3C.3a viruses in USA. The vaccine A(H3N2) components of that year, A/Singapore/INFIMH-16-0019/2016-(H3N2)-like-viruses, belonged to clade-3C.2a1. The circulation of different influenza subtypes and clades of A(H3N2) viruses in a single season highlights the need for universal influenza vaccines.

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Diversity in the circulation of influenza a(H3n2) viruses in the northern hemisphere in the 2018–19 season

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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