Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Sonja I. Berndt; Joseph Vijai; Yolanda Benavente; Nicola J. Camp; Alexandra Nieters; Zhaoming Wang; Karin E. Smedby; Geffen Kleinstern; Henrik Hjalgrim; Caroline Besson; Christine F. Skibola; Lindsay M. Morton; Angela R. Brooks-Wilson; Lauren R. Teras; Charles Breeze; Joshua Arias; Hans Olov Adami; Demetrius Albanes; Kenneth C. Anderson; Stephen M. Ansell; Bryan Bassig; Nikolaus Becker; Parveen Bhatti; Brenda M. Birmann; Paolo Boffetta; Paige M. Bracci; Paul Brennan; Elizabeth E. Brown; Laurie Burdett; Lisa A. Cannon-Albright; Ellen T. Chang; Brian C.H. Chiu; Charles C. Chung; Jacqueline Clavel; Pierluigi Cocco; Graham Colditz; Lucia Conde; David V. Conti; David G. Cox; Karen Curtin; Delphine Casabonne; Immaculata De Vivo; W. Ryan Diver; Ahmet Dogan; Christopher K. Edlund; Lenka Foretova; Joseph F. Fraumeni; Attilio Gabbas; Hervé Ghesquières; Graham G. Giles; Sally Glaser; Martha Glenn; Bengt Glimelius; Jian Gu; Thomas M. Habermann; Christopher A. Haiman; Corinne Haioun; Jonathan N. Hofmann; Theodore R. Holford; Elizabeth A. Holly; Amy Hutchinson; Aalin Izhar; Rebecca D. Jackson; Ruth F. Jarrett; Rudolph Kaaks; Eleanor Kane; Laurence N. Kolonel; Yinfei Kong; Peter Kraft; Anne Kricker; Annette Lake; Qing Lan; Charles Lawrence; Dalin Li; Mark Liebow; Brian K. Link; Corrado Magnani; Marc Maynadie; James McKay; Mads Melbye; Lucia Miligi; Roger L. Milne; Thierry J. Molina; Alain Monnereau; Rebecca Montalvan; Kari E. North; Anne J. Novak; Kenan Onel; Mark P. Purdue; Kristin A. Rand; Elio Riboli; Jacques Riby; Eve Roman; Gilles Salles; Douglas W. Sborov; Richard K. Severson; Tait D. Shanafelt; Martyn T. Smith; Alexandra Smith; Kevin W. Song; Lei Song; Melissa C. Southey; John J. Spinelli; Anthony Staines; Deborah Stephens; Heather J. Sutherland; Kaitlyn Tkachuk; Carrie A. Thompson; Hervé Tilly; Lesley F. Tinker; Ruth C. Travis; Jenny Turner; Celine M. Vachon; Claire M. Vajdic; Anke Van Den Berg; David J. Van Den Berg; Roel C.H. Vermeulen; Paolo Vineis; Sophia S. Wang; Elisabete Weiderpass; George J. Weiner; Stephanie Weinstein; Nicole Wong Doo; Yuanqing Ye; Meredith Yeager; Kai Yu; Anne Zeleniuch-Jacquotte; Yawei Zhang; Tongzhang Zheng; Elad Ziv; Joshua Sampson; Nilanjan Chatterjee; Kenneth Offit; Wendy Cozen; Xifeng Wu; James R. Cerhan; Stephen J. Chanock; Susan L. Slager; Nathaniel Rothman

doi:10.1038/s41375-022-01711-0

Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Sonja I. Berndt, Joseph Vijai, Yolanda Benavente, Nicola J. Camp, Alexandra Nieters, Zhaoming Wang, Karin E. Smedby, Geffen Kleinstern, Henrik Hjalgrim, Caroline Besson, Christine F. Skibola, Lindsay M. Morton, Angela R. Brooks-Wilson, Lauren R. Teras, Charles Breeze, Joshua Arias, Hans Olov Adami, Demetrius Albanes, Kenneth C. Anderson, Stephen M. AnsellBryan Bassig, Nikolaus Becker, Parveen Bhatti, Brenda M. Birmann, Paolo Boffetta, Paige M. Bracci, Paul Brennan, Elizabeth E. Brown, Laurie Burdett, Lisa A. Cannon-Albright, Ellen T. Chang, Brian C.H. Chiu, Charles C. Chung, Jacqueline Clavel, Pierluigi Cocco, Graham Colditz, Lucia Conde, David V. Conti, David G. Cox, Karen Curtin, Delphine Casabonne, Immaculata De Vivo, W. Ryan Diver, Ahmet Dogan, Christopher K. Edlund, Lenka Foretova, Joseph F. Fraumeni, Attilio Gabbas, Hervé Ghesquières, Graham G. Giles, Sally Glaser, Martha Glenn, Bengt Glimelius, Jian Gu, Thomas M. Habermann, Christopher A. Haiman, Corinne Haioun, Jonathan N. Hofmann, Theodore R. Holford, Elizabeth A. Holly, Amy Hutchinson, Aalin Izhar, Rebecca D. Jackson, Ruth F. Jarrett, Rudolph Kaaks, Eleanor Kane, Laurence N. Kolonel, Yinfei Kong, Peter Kraft, Anne Kricker, Annette Lake, Qing Lan, Charles Lawrence, Dalin Li, Mark Liebow, Brian K. Link, Corrado Magnani, Marc Maynadie, James McKay, Mads Melbye, Lucia Miligi, Roger L. Milne, Thierry J. Molina, Alain Monnereau, Rebecca Montalvan, Kari E. North, Anne J. Novak, Kenan Onel, Mark P. Purdue, Kristin A. Rand, Elio Riboli, Jacques Riby, Eve Roman, Gilles Salles, Douglas W. Sborov, Richard K. Severson, Tait D. Shanafelt, Martyn T. Smith, Alexandra Smith, Kevin W. Song, Lei Song, Melissa C. Southey, John J. Spinelli, Anthony Staines, Deborah Stephens, Heather J. Sutherland, Kaitlyn Tkachuk, Carrie A. Thompson, Hervé Tilly, Lesley F. Tinker, Ruth C. Travis, Jenny Turner, Celine M. Vachon, Claire M. Vajdic, Anke Van Den Berg, David J. Van Den Berg, Roel C.H. Vermeulen, Paolo Vineis, Sophia S. Wang, Elisabete Weiderpass, George J. Weiner, Stephanie Weinstein, Nicole Wong Doo, Yuanqing Ye, Meredith Yeager, Kai Yu, Anne Zeleniuch-Jacquotte, Yawei Zhang, Tongzhang Zheng, Elad Ziv, Joshua Sampson, Nilanjan Chatterjee, Kenneth Offit, Wendy Cozen, Xifeng Wu, James R. Cerhan, Stephen J. Chanock, Susan L. Slager, Nathaniel Rothman

School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10⁻⁸) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10⁻⁹). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10⁻⁸), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.

Original language	English
Pages (from-to)	2835-2844
Number of pages	10
Journal	Leukemia
Volume	36
Issue number	12
DOIs	https://doi.org/10.1038/s41375-022-01711-0
State	Published - Dec 2022

Bibliographical note

Publisher Copyright:
© 2022, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.

Keywords

Humans
Genetic Predisposition to Disease
Genome-Wide Association Study
Risk Factors
Lymphoma, Non-Hodgkin/genetics
Germ Cells
Case-Control Studies
Polymorphism, Single Nucleotide

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41375-022-01711-0

Cite this

Berndt, S. I., Vijai, J., Benavente, Y., Camp, N. J., Nieters, A., Wang, Z., Smedby, K. E., Kleinstern, G., Hjalgrim, H., Besson, C., Skibola, C. F., Morton, L. M., Brooks-Wilson, A. R., Teras, L. R., Breeze, C., Arias, J., Adami, H. O., Albanes, D., Anderson, K. C., ... Rothman, N. (2022). Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. Leukemia, 36(12), 2835-2844. https://doi.org/10.1038/s41375-022-01711-0

@article{f064bc86be1740969be5534e73a6fb97,

title = "Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes",

abstract = "Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10−8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10−9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10−8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.",

keywords = "Humans, Genetic Predisposition to Disease, Genome-Wide Association Study, Risk Factors, Lymphoma, Non-Hodgkin/genetics, Germ Cells, Case-Control Studies, Polymorphism, Single Nucleotide",

author = "Berndt, {Sonja I.} and Joseph Vijai and Yolanda Benavente and Camp, {Nicola J.} and Alexandra Nieters and Zhaoming Wang and Smedby, {Karin E.} and Geffen Kleinstern and Henrik Hjalgrim and Caroline Besson and Skibola, {Christine F.} and Morton, {Lindsay M.} and Brooks-Wilson, {Angela R.} and Teras, {Lauren R.} and Charles Breeze and Joshua Arias and Adami, {Hans Olov} and Demetrius Albanes and Anderson, {Kenneth C.} and Ansell, {Stephen M.} and Bryan Bassig and Nikolaus Becker and Parveen Bhatti and Birmann, {Brenda M.} and Paolo Boffetta and Bracci, {Paige M.} and Paul Brennan and Brown, {Elizabeth E.} and Laurie Burdett and Cannon-Albright, {Lisa A.} and Chang, {Ellen T.} and Chiu, {Brian C.H.} and Chung, {Charles C.} and Jacqueline Clavel and Pierluigi Cocco and Graham Colditz and Lucia Conde and Conti, {David V.} and Cox, {David G.} and Karen Curtin and Delphine Casabonne and {De Vivo}, Immaculata and Diver, {W. Ryan} and Ahmet Dogan and Edlund, {Christopher K.} and Lenka Foretova and Fraumeni, {Joseph F.} and Attilio Gabbas and Herv{\'e} Ghesqui{\`e}res and Giles, {Graham G.} and Sally Glaser and Martha Glenn and Bengt Glimelius and Jian Gu and Habermann, {Thomas M.} and Haiman, {Christopher A.} and Corinne Haioun and Hofmann, {Jonathan N.} and Holford, {Theodore R.} and Holly, {Elizabeth A.} and Amy Hutchinson and Aalin Izhar and Jackson, {Rebecca D.} and Jarrett, {Ruth F.} and Rudolph Kaaks and Eleanor Kane and Kolonel, {Laurence N.} and Yinfei Kong and Peter Kraft and Anne Kricker and Annette Lake and Qing Lan and Charles Lawrence and Dalin Li and Mark Liebow and Link, {Brian K.} and Corrado Magnani and Marc Maynadie and James McKay and Mads Melbye and Lucia Miligi and Milne, {Roger L.} and Molina, {Thierry J.} and Alain Monnereau and Rebecca Montalvan and North, {Kari E.} and Novak, {Anne J.} and Kenan Onel and Purdue, {Mark P.} and Rand, {Kristin A.} and Elio Riboli and Jacques Riby and Eve Roman and Gilles Salles and Sborov, {Douglas W.} and Severson, {Richard K.} and Shanafelt, {Tait D.} and Smith, {Martyn T.} and Alexandra Smith and Song, {Kevin W.} and Lei Song and Southey, {Melissa C.} and Spinelli, {John J.} and Anthony Staines and Deborah Stephens and Sutherland, {Heather J.} and Kaitlyn Tkachuk and Thompson, {Carrie A.} and Herv{\'e} Tilly and Tinker, {Lesley F.} and Travis, {Ruth C.} and Jenny Turner and Vachon, {Celine M.} and Vajdic, {Claire M.} and {Van Den Berg}, Anke and {Van Den Berg}, {David J.} and Vermeulen, {Roel C.H.} and Paolo Vineis and Wang, {Sophia S.} and Elisabete Weiderpass and Weiner, {George J.} and Stephanie Weinstein and Doo, {Nicole Wong} and Yuanqing Ye and Meredith Yeager and Kai Yu and Anne Zeleniuch-Jacquotte and Yawei Zhang and Tongzhang Zheng and Elad Ziv and Joshua Sampson and Nilanjan Chatterjee and Kenneth Offit and Wendy Cozen and Xifeng Wu and Cerhan, {James R.} and Chanock, {Stephen J.} and Slager, {Susan L.} and Nathaniel Rothman",

note = "Publisher Copyright: {\textcopyright} 2022, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.",

year = "2022",

month = dec,

doi = "10.1038/s41375-022-01711-0",

language = "English",

volume = "36",

pages = "2835--2844",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Springer Nature",

number = "12",

}

Berndt, SI, Vijai, J, Benavente, Y, Camp, NJ, Nieters, A, Wang, Z, Smedby, KE, Kleinstern, G, Hjalgrim, H, Besson, C, Skibola, CF, Morton, LM, Brooks-Wilson, AR, Teras, LR, Breeze, C, Arias, J, Adami, HO, Albanes, D, Anderson, KC, Ansell, SM, Bassig, B, Becker, N, Bhatti, P, Birmann, BM, Boffetta, P, Bracci, PM, Brennan, P, Brown, EE, Burdett, L, Cannon-Albright, LA, Chang, ET, Chiu, BCH, Chung, CC, Clavel, J, Cocco, P, Colditz, G, Conde, L, Conti, DV, Cox, DG, Curtin, K, Casabonne, D, De Vivo, I, Diver, WR, Dogan, A, Edlund, CK, Foretova, L, Fraumeni, JF, Gabbas, A, Ghesquières, H, Giles, GG, Glaser, S, Glenn, M, Glimelius, B, Gu, J, Habermann, TM, Haiman, CA, Haioun, C, Hofmann, JN, Holford, TR, Holly, EA, Hutchinson, A, Izhar, A, Jackson, RD, Jarrett, RF, Kaaks, R, Kane, E, Kolonel, LN, Kong, Y, Kraft, P, Kricker, A, Lake, A, Lan, Q, Lawrence, C, Li, D, Liebow, M, Link, BK, Magnani, C, Maynadie, M, McKay, J, Melbye, M, Miligi, L, Milne, RL, Molina, TJ, Monnereau, A, Montalvan, R, North, KE, Novak, AJ, Onel, K, Purdue, MP, Rand, KA, Riboli, E, Riby, J, Roman, E, Salles, G, Sborov, DW, Severson, RK, Shanafelt, TD, Smith, MT, Smith, A, Song, KW, Song, L, Southey, MC, Spinelli, JJ, Staines, A, Stephens, D, Sutherland, HJ, Tkachuk, K, Thompson, CA, Tilly, H, Tinker, LF, Travis, RC, Turner, J, Vachon, CM, Vajdic, CM, Van Den Berg, A, Van Den Berg, DJ, Vermeulen, RCH, Vineis, P, Wang, SS, Weiderpass, E, Weiner, GJ, Weinstein, S, Doo, NW, Ye, Y, Yeager, M, Yu, K, Zeleniuch-Jacquotte, A, Zhang, Y, Zheng, T, Ziv, E, Sampson, J, Chatterjee, N, Offit, K, Cozen, W, Wu, X, Cerhan, JR, Chanock, SJ, Slager, SL & Rothman, N 2022, 'Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes', Leukemia, vol. 36, no. 12, pp. 2835-2844. https://doi.org/10.1038/s41375-022-01711-0

TY - JOUR

T1 - Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

AU - Berndt, Sonja I.

AU - Vijai, Joseph

AU - Benavente, Yolanda

AU - Camp, Nicola J.

AU - Nieters, Alexandra

AU - Wang, Zhaoming

AU - Smedby, Karin E.

AU - Kleinstern, Geffen

AU - Hjalgrim, Henrik

AU - Besson, Caroline

AU - Skibola, Christine F.

AU - Morton, Lindsay M.

AU - Brooks-Wilson, Angela R.

AU - Teras, Lauren R.

AU - Breeze, Charles

AU - Arias, Joshua

AU - Adami, Hans Olov

AU - Albanes, Demetrius

AU - Anderson, Kenneth C.

AU - Ansell, Stephen M.

AU - Bassig, Bryan

AU - Becker, Nikolaus

AU - Bhatti, Parveen

AU - Birmann, Brenda M.

AU - Boffetta, Paolo

AU - Bracci, Paige M.

AU - Brennan, Paul

AU - Brown, Elizabeth E.

AU - Burdett, Laurie

AU - Cannon-Albright, Lisa A.

AU - Chang, Ellen T.

AU - Chiu, Brian C.H.

AU - Chung, Charles C.

AU - Clavel, Jacqueline

AU - Cocco, Pierluigi

AU - Colditz, Graham

AU - Conde, Lucia

AU - Conti, David V.

AU - Cox, David G.

AU - Curtin, Karen

AU - Casabonne, Delphine

AU - De Vivo, Immaculata

AU - Diver, W. Ryan

AU - Dogan, Ahmet

AU - Edlund, Christopher K.

AU - Foretova, Lenka

AU - Fraumeni, Joseph F.

AU - Gabbas, Attilio

AU - Ghesquières, Hervé

AU - Giles, Graham G.

AU - Glaser, Sally

AU - Glenn, Martha

AU - Glimelius, Bengt

AU - Gu, Jian

AU - Habermann, Thomas M.

AU - Haiman, Christopher A.

AU - Haioun, Corinne

AU - Hofmann, Jonathan N.

AU - Holford, Theodore R.

AU - Holly, Elizabeth A.

AU - Hutchinson, Amy

AU - Izhar, Aalin

AU - Jackson, Rebecca D.

AU - Jarrett, Ruth F.

AU - Kaaks, Rudolph

AU - Kane, Eleanor

AU - Kolonel, Laurence N.

AU - Kong, Yinfei

AU - Kraft, Peter

AU - Kricker, Anne

AU - Lake, Annette

AU - Lan, Qing

AU - Lawrence, Charles

AU - Li, Dalin

AU - Liebow, Mark

AU - Link, Brian K.

AU - Magnani, Corrado

AU - Maynadie, Marc

AU - McKay, James

AU - Melbye, Mads

AU - Miligi, Lucia

AU - Milne, Roger L.

AU - Molina, Thierry J.

AU - Monnereau, Alain

AU - Montalvan, Rebecca

AU - North, Kari E.

AU - Novak, Anne J.

AU - Onel, Kenan

AU - Purdue, Mark P.

AU - Rand, Kristin A.

AU - Riboli, Elio

AU - Riby, Jacques

AU - Roman, Eve

AU - Salles, Gilles

AU - Sborov, Douglas W.

AU - Severson, Richard K.

AU - Shanafelt, Tait D.

AU - Smith, Martyn T.

AU - Smith, Alexandra

AU - Song, Kevin W.

AU - Song, Lei

AU - Southey, Melissa C.

AU - Spinelli, John J.

AU - Staines, Anthony

AU - Stephens, Deborah

AU - Sutherland, Heather J.

AU - Tkachuk, Kaitlyn

AU - Thompson, Carrie A.

AU - Tilly, Hervé

AU - Tinker, Lesley F.

AU - Travis, Ruth C.

AU - Turner, Jenny

AU - Vachon, Celine M.

AU - Vajdic, Claire M.

AU - Van Den Berg, Anke

AU - Van Den Berg, David J.

AU - Vermeulen, Roel C.H.

AU - Vineis, Paolo

AU - Wang, Sophia S.

AU - Weiderpass, Elisabete

AU - Weiner, George J.

AU - Weinstein, Stephanie

AU - Doo, Nicole Wong

AU - Ye, Yuanqing

AU - Yeager, Meredith

AU - Yu, Kai

AU - Zeleniuch-Jacquotte, Anne

AU - Zhang, Yawei

AU - Zheng, Tongzhang

AU - Ziv, Elad

AU - Sampson, Joshua

AU - Chatterjee, Nilanjan

AU - Offit, Kenneth

AU - Cozen, Wendy

AU - Wu, Xifeng

AU - Cerhan, James R.

AU - Chanock, Stephen J.

AU - Slager, Susan L.

AU - Rothman, Nathaniel

PY - 2022/12

Y1 - 2022/12

N2 - Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10−8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10−9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10−8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.

AB - Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10−8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10−9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10−8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.

KW - Humans

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Risk Factors

KW - Lymphoma, Non-Hodgkin/genetics

KW - Germ Cells

KW - Case-Control Studies

KW - Polymorphism, Single Nucleotide

UR - http://www.scopus.com/inward/record.url?scp=85140325134&partnerID=8YFLogxK

U2 - 10.1038/s41375-022-01711-0

DO - 10.1038/s41375-022-01711-0

M3 - Article

C2 - 36273105

AN - SCOPUS:85140325134

SN - 0887-6924

VL - 36

SP - 2835

EP - 2844

JO - Leukemia

JF - Leukemia

IS - 12

ER -

Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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