Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information

Hadas Nahman-Averbuch, Katherine T. Martucci, Yelena Granovsky, Irit Weissman-Fogel, David Yarnitsky, Robert C. Coghill

Research output: Contribution to journalArticlepeer-review

Abstract

The role of endogenous analgesic mechanisms has largely been viewed in the context of gain modulation during nociceptive processing. However, these analgesic mechanisms may play critical roles in the extraction and subsequent utilization of information related to spatial and temporal features of nociceptive input. To date, it remains unknown if spatial and temporal filtering of nociceptive information is supported by similar analgesic mechanisms. To address this question, human volunteers were recruited to assess brain activation with functional magnetic resonance imaging during conditioned pain modulation (CPM) and offset analgesia (OA). CPM provides one paradigm for assessing spatial filtering of nociceptive information while OA provides a paradigm for assessing temporal filtering of nociceptive information. CPM and OA both produced statistically significant reductions in pain intensity. However, the magnitude of pain reduction elicited by CPM was not correlated with that elicited by OA across different individuals. Different patterns of brain activation were consistent with the psychophysical findings. CPM elicited widespread reductions in regions engaged in nociceptive processing such as the thalamus, insula, and secondary somatosensory cortex. OA produced reduced activity in the primary somatosensory cortex but was associated with greater activation in the anterior insula, dorsolateral prefrontal cortex, intrapa-rietal sulcus, and inferior parietal lobule relative to CPM. In the brain stem, CPM consistently produced reductions in activity, while OA produced increases in activity. Conjunction analysis confirmed that CPM-related activity did not overlap with that of OA. Thus, dissociable mechanisms support inhibitory processes engaged during spatial vs temporal filtering of nociceptive information.

Original languageEnglish
Pages (from-to)2491-2501
Number of pages11
JournalPain
Volume155
Issue number12
DOIs
StatePublished - 2014

Bibliographical note

Funding Information:
Supported by a United States-Israel Binational Science Foundation (BSF) (grant 2009097 ) and the NIH (grants R01 NS039426 and NIH F31DA026278 ).

Publisher Copyright:
© 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

Keywords

  • CPM
  • Conditioned pain modulation
  • Offset analgesia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Fingerprint

Dive into the research topics of 'Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information'. Together they form a unique fingerprint.

Cite this