Dissociating value representation and inhibition of inappropriate affective response during reversal learning in the ventromedial prefrontal cortex

Zhihao Zhang, Avi Mendelsohn, Kirk F. Manson, Daniela Schiller, Ifat Levy

Research output: Contribution to journalArticlepeer-review

Abstract

Decision-making studies have implicated the ventromedial prefrontal cortex (vmPFC) in tracking the value of rewards and punishments. At the same time, fear-learning studies have pointed to a role of the same area in updating previously learned cue–outcome associations. To disentangle these accounts, we used a reward reversal-learning paradigm in a functional magnetic resonance imaging study in 18 human participants. Participants first learned that one of two colored squares (color A) was associated with monetary reward, whereas the other (color B) was not, and then had to learn that these contingencies reversed. Consistent with value representation, activity of a dorsal region of vmPFC was positively correlated with reward magnitude. Conversely, a more ventral region of vmPFC responded more to color A than to color B after contingency reversal, compatible with a role of inhibiting the previously learned response that was no longer appropriate. Moreover, the response strength was correlated with subjects’ behavioral learning strength. Our findings provide direct evidence for the spatial dissociation of value representation and affective response inhibition in the vmPFC.

Original languageEnglish
Article numbere0072-15.2015
JournaleNeuro
Volume2
Issue number6
DOIs
StatePublished - 1 Nov 2015

Bibliographical note

Funding Information:
This work was funded by NIH/NIMH Grant R21MH102634 and CTSA Grant (UL1 TR000142) from the National Center for Advancing Translational Science (NCATS) to I.L., and by NIH/NIMH Grant R01MH105515 and a Klingenstein-Simons Fellowship Award in the Neurosciences to D.S.; the contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH. We thank John O’Doherty for the original idea for this study and Ruonan Jia and Eric Feltham for helpful comments on the manuscript.

Funding Information:
3This work was funded by NIH/NIMH Grant R21MH102634 and CTSA Grant (UL1 TR000142) from the National Center for Advancing Translational Science (NCATS) to I.L., and by NIH/NIMH Grant R01MH105515 and a Klingenstein-Simons Fellowship Award in the Neurosciences to D.S.; the contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH. We thank John O’Doherty for the original idea for this study and Ruonan Jia and Eric Feltham for helpful comments on the manuscript.

Publisher Copyright:
© 2015 Zhang et al.

Keywords

  • Conditioning
  • Human
  • Reward-learning
  • Valuation
  • fMRI

ASJC Scopus subject areas

  • Neuroscience (all)

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