Dissociable cortico-striatal connectivity abnormalities in major depression in response to monetary gains and penalties

R. Admon, L. D. Nickerson, D. G. Dillon, A. J. Holmes, R. Bogdan, P. Kumar, D. D. Dougherty, D. V. Iosifescu, D. Mischoulon, M. Fava, D. A. Pizzagalli

Research output: Contribution to journalArticlepeer-review


Background. Individuals with major depressive disorder (MDD) are characterized by maladaptive responses to both positive and negative outcomes, which have been linked to localized abnormal activations in cortical and striatal brain regions. However, the exact neural circuitry implicated in such abnormalities remains largely unexplored. Method. In this study 26 unmedicated adults with MDD and 29 matched healthy controls (HCs) completed a monetary incentive delay task during functional magnetic resonance imaging (fMRI). Psychophysiological interaction (PPI) analyses probed group differences in connectivity separately in response to positive and negative outcomes (i.e. monetary gains and penalties). Results. Relative to HCs, MDD subjects displayed decreased connectivity between the caudate and dorsal anterior cingulate cortex (dACC) in response to monetary gains, yet increased connectivity between the caudate and a different, more rostral, dACC subregion in response to monetary penalties. Moreover, exploratory analyses of 14 MDD patients who completed a 12-week, double-blind, placebo-controlled clinical trial after the baseline fMRI scans indicated that a more normative pattern of cortico-striatal connectivity pre-treatment was associated with greater improvement in symptoms 12 weeks later. Conclusions. These results identify the caudate as a region with dissociable incentive-dependent dACC connectivity abnormalities in MDD, and provide initial evidence that cortico-striatal circuitry may play a role in MDD treatment response. Given the role of cortico-striatal circuitry in encoding action-outcome contingencies, such dysregulated connectivity may relate to the prominent disruptions in goal-directed behavior that characterize MDD.

Original languageEnglish
Pages (from-to)121-131
Number of pages11
JournalPsychological Medicine
Issue number1
StatePublished - 12 Jan 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2014 Cambridge University Press.


  • Caudate
  • PPI
  • cingulate
  • depression
  • reward
  • treatment prediction

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health


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