Dissection of the Functional Surface of an Anti-insect Excitatory Toxin Illuminates a Putative "Hot Spot" Common to All Scorpion β-Toxins Affecting Na⁺ Channels

Keyphrases

• Na + 100%
• Scorpion Toxin 100%
• Anti-insect 100%
• Functional Surface 100%
• Receptor Binding 50%
• Structural Change 50%
• Unique Structure 50%
• Scorpion 50%
• Bioactivity 50%
• Voltage-gated Sodium Channel 50%
• Efficient System 50%
• Active Sites 50%
• Binding Interface 50%
• Toxicity Assay 50%
• Discontinuity Surfaces 50%
• Polar Regions 50%
• Circular Dichroism Spectroscopy 50%
• Channel Gating 50%
• Binding Assay 50%
• Receptor Sites 50%
• Toxin Receptor 50%
• Helical Motif 50%
• Charged Residue 50%
• Pharmacophore 50%
• C-terminal Region 50%
• Charged Amino Acids 50%
• Bulk Solvent 50%
• Gasket 50%
• Channel Architecture 50%
• Point mutagenesis 50%
• Recombinant Toxin 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Receptor 100%
• Sodium Channel 100%
• Scorpion Toxin 100%
• Scorpion 50%
• Mutagenesis 50%
• Amino Acid 50%
• Voltage Gated Sodium Channel 50%