Disrupted axonal fiber connectivity as a marker of impaired consciousness states

Rafael Rodriguez-Rojas, Karla Batista, Yasser Iturria, Calixto Machado, Gerry Leisman, Mauricio Chinchilla, Philip DeFina, Maylen Carballo, Juan M. Morales

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Persistent vegetative states (PVS) and locked-in syndrome (LIS) are well-differentiated disorders of consciousness that can be reached after a localized brain injury in the brainstem. The relations of the lesion topography with the impairment in the whole-brain architecture and functional disconnections are poorly understood. Methods: Two patients (PVS and LIS) and 20 age-matched healthy volunteers were evaluated using diffusion tensor imaging (DTI). Anatomical network was modeled as a graph whose nodes are represented by 71 brain regions. Inter-region connections were quantified through Anatomical Connection Strength (ACS) and Density (ACD). Complex networks properties such as local and global efficiency and vulnerability were studied. Mass univariate testing was performed at every connection using network based statistic approach. Results: LIS patients’ network showed significant differences from controls in the brainstem-thalamus-frontal cortex circuitry, while PVS patients showed a widespread disruption of anatomical connectivity in both hemispheres. Both patients showed a reorganization of network attributes, with decreased global and local efficiency, significantly more pronounced in PVS. Conclusions: Our results suggest that DTI-based network connectivity combined with graph theory is useful to study the long-range effect of confined injuries and the relationship to the degree of consciousness impairment, underlying PVS and LIS.

Original languageEnglish
Title of host publicationConsidering Consciousness Clinically
PublisherNova Science Publishers, Inc.
Number of pages11
ISBN (Electronic)9781634842617
ISBN (Print)9781634842600
StatePublished - 1 Jan 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 by Nova Science Publishers, Inc. All rights reserved.

ASJC Scopus subject areas

  • Medicine (all)


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