Dioxin-like biological activity of organic extracts from sediments and fish livers sampled along the Israeli Mediterranean and Red Sea coasts

Yana Yudkovski, Barak Herut, Edna Shefer, Moshe Tom

Research output: Contribution to journalArticlepeer-review


This study provides, for the first time, a baseline evaluation of dioxin-like biological activity in sediments and fish sampled in- and adjacent to anchorages along the Mediterranean and Red Sea coasts of Israel. It indicates the effect of past pollution, still present in the sediments of older Israeli harbors, with putative contribution of still existing sources of pollution. A commercial reporter gene bioassay was used to evaluate the biological activity of dioxin-like compounds extracted from the samples. HRGC/HRMS analysis of several samples contributed a profile of dioxin-like compounds in sediments and fish. The results point out 1,2,3,4,6,7,8-HeptaCDD, 2,3,4,6,7,8-HexaCDF, 1,2,3,4,6,7,8-HeptaCDF, R{cyrillic}s{cyrillic}V{cyrillic}-126 and R{cyrillic}s{cyrillic}V{cyrillic}-118 as major contributors to the dioxin-like activity in sediments. It indicates polychlorinated biphenyls non-selective absorption in fish livers, in contrary to a biased accumulation of poorly chlorinated and more potent dibenzodioxins and dibenzofurans.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalMarine Pollution Bulletin
Issue number1-2
StatePublished - 15 Sep 2015
Externally publishedYes

Bibliographical note

Funding Information:
The study was supported by the European Union PF7 program grant, Perseus (287600) to M.T. and B.H., Israel Ministry of infrastructure grant (29-17-054) to M.T. and B.H., Israel Ministry of Environmental Protection, grant (103-12-4) to M.T. and Y.Y. Dr. Peter Behnisch and Mr. Emiel Felzel from BioDtection Systems, Amsterdam, are thanked for their kind advices and assistance during the performance of the biological and GCMS evaluations. The assistance of Dr. Maya Marmori from the Chemistry department of the Israel Oceanographic and Limnological Research in operating the MARSexpress device and in providing fish samples is appreciated. And last, the English editing of Ms. Lilach Baumer is thanked.

Publisher Copyright:
© 2015 Elsevier Ltd.


  • DR-CALUX reporter gene assay
  • Dioxin-like activity
  • Israel coastal environment
  • Polychlorinated biphenyls
  • Polychlorinated dibenzodioxins/dibenzofurans

ASJC Scopus subject areas

  • Oceanography
  • Aquatic Science
  • Pollution


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