Differential modulation of brain immediate early genes by intraperitoneal LiCI

Raphael Lamprecht; Yadin Dudai

doi:10.1097/00001756-199512000-00069

Differential modulation of brain immediate early genes by intraperitoneal LiCI

Research output: Contribution to journal › Article › peer-review

Abstract

We have used in situ hybridization to investigate the modulation of expression of the immediate early genes (IEGs) c-fos, fos-B, zif/268 and CREM in rat brain following oral administration of saccharin, i.p. injection of LiCl, and conditioned taste aversion (CTA) training in which these stimuli are used as the conditioned stimulus (CS) and the unconditioned stimulus (UCS), respectively. Modulation of c-fos, zif/268 and CREM was detected in the NTS, PBN, hypothalamic PVN and central nucleus of the amygdala after the administration of the UCS but not the CS. Our data are consonant with the hypothesis that differential and combinatorial expression of IEGs plays a role in encoding the representation of LiCl-induced malaise in the brain.

Original language	English
Pages (from-to)	289-293
Number of pages	5
Journal	NeuroReport
Volume	7
Issue number	1
DOIs	https://doi.org/10.1097/00001756-199512000-00069
State	Published - 29 Dec 1995
Externally published	Yes

Keywords

C-fos
CREM
Conditioned taste aversion
Fos-B
Immediate early genes
Zif/268

ASJC Scopus subject areas

General Neuroscience

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10.1097/00001756-199512000-00069

Cite this

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abstract = "We have used in situ hybridization to investigate the modulation of expression of the immediate early genes (IEGs) c-fos, fos-B, zif/268 and CREM in rat brain following oral administration of saccharin, i.p. injection of LiCl, and conditioned taste aversion (CTA) training in which these stimuli are used as the conditioned stimulus (CS) and the unconditioned stimulus (UCS), respectively. Modulation of c-fos, zif/268 and CREM was detected in the NTS, PBN, hypothalamic PVN and central nucleus of the amygdala after the administration of the UCS but not the CS. Our data are consonant with the hypothesis that differential and combinatorial expression of IEGs plays a role in encoding the representation of LiCl-induced malaise in the brain.",

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AU - Dudai, Yadin

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Differential modulation of brain immediate early genes by intraperitoneal LiCI

Abstract

Keywords

ASJC Scopus subject areas

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