Differential modulation of brain immediate early genes by intraperitoneal LiCI

Raphael Lamprecht, Yadin Dudai

Research output: Contribution to journalArticlepeer-review


We have used in situ hybridization to investigate the modulation of expression of the immediate early genes (IEGs) c-fos, fos-B, zif/268 and CREM in rat brain following oral administration of saccharin, i.p. injection of LiCl, and conditioned taste aversion (CTA) training in which these stimuli are used as the conditioned stimulus (CS) and the unconditioned stimulus (UCS), respectively. Modulation of c-fos, zif/268 and CREM was detected in the NTS, PBN, hypothalamic PVN and central nucleus of the amygdala after the administration of the UCS but not the CS. Our data are consonant with the hypothesis that differential and combinatorial expression of IEGs plays a role in encoding the representation of LiCl-induced malaise in the brain.

Original languageEnglish
Pages (from-to)289-293
Number of pages5
Issue number1
StatePublished - 29 Dec 1995
Externally publishedYes


  • C-fos
  • CREM
  • Conditioned taste aversion
  • Fos-B
  • Immediate early genes
  • Zif/268

ASJC Scopus subject areas

  • General Neuroscience


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