Different effects of low frequency stimulation to infralimbic prefrontal cortex on extinction of aversive memories

Kamilia Shehadi, Mouna Maroun

Research output: Contribution to journalArticlepeer-review


Experimental extinction is a behavioral technique in which animals learn to extinguish previously learned fear responses. The infralimbic cortex (IL) of the medial prefrontal cortex has an important role in extinction of aversive memories. We have recently shown that electrical stimulation of the IL in a form of high-frequency stimulation (HFS), which induces potentiation in the IL, was associated with enhanced ability to extinguish aversive memory in two aversive paradigms, the fear conditioning and the conditioned taste aversion paradigms. These results suggest that the induction of potentiation in the IL is associated with better ability to extinguish. In the present study we examined the opposite hypothesis that inducing depression in the IL by the application of low-frequency stimulation (LFS) will result in impairments in extinction. Our results show that the application of LFS to the IL retards extinction of fear conditioning only, suggesting that the application of LFS to the IL results in impairments in extinction of conditioned fear. In the conditioned taste aversion paradigm (CTA), LFS to the IL was associated with delayed enhancement of extinction of CTA that was apparent 48 h following stimulation. These results suggest that localized electrical stimulation to the IL may be an effective method for manipulating learned fear and affecting the ability to extinguish aversive associations.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalBrain Research
StatePublished - 15 Jan 2013

Bibliographical note

Funding Information:
This research was supported by the Israel Ministry of Health to Mouna Maroun.


  • Extinction
  • Infralimbic
  • Rat
  • Synaptic plasticity
  • mPFC

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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