Dietary vitamin E and C intake is inversely associated with the severity of nonalcoholic fatty liver disease

Dana Ivancovsky-Wajcman, Naomi Fliss-Isakov, Federico Salomone, Muriel Webb, Oren Shibolet, Revital Kariv, Shira Zelber-Sagi

Research output: Contribution to journalArticlepeer-review


Background & aims: Although antioxidants have a protective potential in nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH), there is limited evidence regarding the role of dietary intake of antioxidants. The aim was to test the association between dietary vitamins E and C intake and NAFLD, NASH and fibrosis markers. Methods: Cross-sectional study of a large cohort of subjects undergoing colonoscopy. The presence of NAFLD was evaluated by ultrasonography. The level of steatosis was defined using SteatoTest, moderate-severe NASH using new quantitative NashTest and borderline-significant fibrosis ≥ F1–F2 using FibroTest. Nutritional intake was measured by food frequency questionnaire (FFQ). Results: Overall, 789 subjects were included (52.6% men, age 58.83 ± 6.58 years), 714 had reliable FibroMax. Adjusting for BMI, dietary and lifestyle factors, the upper tertile of vitamin E intake/1000 Kcal was associated with lower odds of NASH (OR = 0.64, 0.43–0.94, P = 0.024). There was an inverse association between reaching the recommended vitamin E intake and NASH (OR = 0.48, 0.30–0.77, P = 0.002). The upper tertile of vitamin C intake/1000 Kcal was associated with lower odds of NAFLD and NASH (OR = 0.68, 0.47–0.99, P = 0.045; OR = 0.57, 0.38–0.84, P = 0.004, respectively). Both vitamins were related with the level of steatosis according to SteatoTest. Conclusion: Vitamin E and C intake may be protective from NAFLD-related liver damage.

Original languageEnglish
Pages (from-to)1698-1705
Number of pages8
JournalDigestive and Liver Disease
Issue number12
StatePublished - Dec 2019

Bibliographical note

Funding Information:
Research Grants and Fellowships Fund on Food and Nutrition and their Implications on Public Health, The Israeli Ministry of Health.

Publisher Copyright:
© 2019 Editrice Gastroenterologica Italiana S.r.l.


  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis
  • Vitamin C
  • Vitamin E

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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