Development and validation of the mobility in middle-age questionnaire

Roee Hayek, Carrie A. Karvonen-Gutierrez, Jonathan F. Bean, Jack M. Guralnik, Kenneth Covinsky, Jay R. Hoffman, Michal Azmon, Galit Yogev-Seligmann, Gregory Krautner, Odelyah Saad, Yaniv Nudelman, Rebecca T. Brown, Shmuel Springer

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Mobility decline often begins in midlife, and early identification of individuals at risk of accelerated deterioration can enable timely prevention. However, there is no validated self-report instrument that specifically assesses mobility in the middle-aged population. Methods: The Mobility in Middle-Age Questionnaire (MMQ) was developed through a 7-step Delphi process, consisting of 10 experts, involving item selection and content validation in both English and Hebrew, comprising 2 factors: (1) Current Mobility Ability and (2) 1-Year Mobility Change. Psychometric properties were assessed in 610 US and 594 Israeli middle-aged adults. Analyses included internal consistency, test–retest reliability, structural and construct validity (using the 10-item Physical Functioning scale [PF-10] from SF-36), and floor/ceiling effect assessments. A “Potential Mobility Risk Zone” was defined as the lowest 20% of MMQ scores. Results: The MMQ showed excellent internal consistency (Cronbach’s α=.94 English; .92 Hebrew) and strong test–retest reliability (intraclass correlation coefficient=0.89-0.90). Exploratory factor analysis explained 66% of variance; confirmatory factor analysis showed good fit (Comparative Fit Index=0.99, Tucker–Lewis Index=0.99, Standardized Root Mean Square Residual=0.05). Construct validity was supported, with all pre-defined hypotheses confirmed. MMQ showed significantly lower ceiling effects than PF-10 (3.9% vs. 34.5% in United States; 0.17% vs 25.25% in Israel, p < .001, large effect sizes). A score of 50 (20th percentile) was proposed as a preliminary “Potential Mobility Risk” Threshold. Conclusions: The MMQ is a reliable and valid tool for detecting early mobility decline in midlife. Longitudinal studies are needed to confirm its predictive value and responsiveness to change.

Original languageEnglish
Article numberglaf205
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume80
Issue number12
DOIs
StatePublished - 1 Dec 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2025. Published by Oxford University Press on behalf of the Gerontological Society of America.

Keywords

  • Aging
  • Delphi
  • Early-detection
  • Mid-life
  • Self-reported

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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