Developing of focal ischemia in the hippocampus or the amygdala reveals a regional compensation rule for fear memory acquisition

Cheng Long Yu; Jin Nan Li; Ping Gan; Li Ping Wang; Yue Xiong Yang; Da Fu Yu; Rong Rong Mao; Fu Qiang Xu; Qi Xin Zhou; Gal Richter-Levin; Lin Xu; Heng Zhou

doi:10.1523/ENEURO.0398-20.2021

Developing of focal ischemia in the hippocampus or the amygdala reveals a regional compensation rule for fear memory acquisition

Cheng Long Yu, Jin Nan Li, Ping Gan, Li Ping Wang, Yue Xiong Yang, Da Fu Yu, Rong Rong Mao, Fu Qiang Xu, Qi Xin Zhou, Gal Richter-Levin, Lin Xu, Heng Zhou

Research output: Contribution to journal › Article › peer-review

Abstract

Circuit compensation is often observed in patients with acute ischemic stroke, suggesting the importance of the interaction between brain regions. Also, contextual fear memory is an association between multisensory contexts and fearful stimuli, for which the interaction between the hippocampus and the amygdala is believed to be critical. To understand how focal ischemia in one region could influence the other region, we used a modified photo-thrombosis to induce focal ischemia in the hippocampus or the amygdala or both in freely-moving rats. We found that the learning curve and short-term memory (STM) were not affected in the rats although focal ischemia was induced 5 h before learning in either the hippocampus or the amygdala; these were impaired by the induction of ischemia in both the regions. Furthermore, the learning curve and STM were impaired when ischemia was induced 24 h before learning in either the hippocampus or the amygdala when the synaptic transmission was altered in one region because of ischemia in the other region. These results suggest that the circuit compensation between the hippocampus and the amygdala is critical for fear memory acquisition.

Original language	English
Article number	ENEURO.0398-20.2021
Journal	eNeuro
Volume	8
Issue number	2
DOIs	https://doi.org/10.1523/ENEURO.0398-20.2021
State	Published - 2021

Bibliographical note

Funding Information:
This work was supported by Natural Science Foundation of China Grants 31100775 and 31371141 (to Q.-X.Z.), U15022058 (to L.X.), 31860272 (to P.G.), and 31861143037 (to L.X. and G.R.-L.); the Strategic Priority Research Program of the Chinese Academy of Sciences Grant XDB32020000 (to L.X.); the Department of Science and Technology Program of Yunnan Province Grant 2016HA002 (to L.X.); the External Cooperation Program BIC of the Chinese Academy of Sciences Grant GJHZ1549 (to G.R.-L.); and the Youth Innovation Promotion Association of the Chinese Academy of Sciences Grant 2013250 (to Q.-X.Z.).

Publisher Copyright:
© 2021 Yu et al.

Keywords

Amygdala
Circuits
Fear memory
Hippocampus
Ischemia

ASJC Scopus subject areas

Neuroscience (all)

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10.1523/ENEURO.0398-20.2021

Cite this

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title = "Developing of focal ischemia in the hippocampus or the amygdala reveals a regional compensation rule for fear memory acquisition",

abstract = "Circuit compensation is often observed in patients with acute ischemic stroke, suggesting the importance of the interaction between brain regions. Also, contextual fear memory is an association between multisensory contexts and fearful stimuli, for which the interaction between the hippocampus and the amygdala is believed to be critical. To understand how focal ischemia in one region could influence the other region, we used a modified photo-thrombosis to induce focal ischemia in the hippocampus or the amygdala or both in freely-moving rats. We found that the learning curve and short-term memory (STM) were not affected in the rats although focal ischemia was induced 5 h before learning in either the hippocampus or the amygdala; these were impaired by the induction of ischemia in both the regions. Furthermore, the learning curve and STM were impaired when ischemia was induced 24 h before learning in either the hippocampus or the amygdala when the synaptic transmission was altered in one region because of ischemia in the other region. These results suggest that the circuit compensation between the hippocampus and the amygdala is critical for fear memory acquisition.",

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note = "Funding Information: This work was supported by Natural Science Foundation of China Grants 31100775 and 31371141 (to Q.-X.Z.), U15022058 (to L.X.), 31860272 (to P.G.), and 31861143037 (to L.X. and G.R.-L.); the Strategic Priority Research Program of the Chinese Academy of Sciences Grant XDB32020000 (to L.X.); the Department of Science and Technology Program of Yunnan Province Grant 2016HA002 (to L.X.); the External Cooperation Program BIC of the Chinese Academy of Sciences Grant GJHZ1549 (to G.R.-L.); and the Youth Innovation Promotion Association of the Chinese Academy of Sciences Grant 2013250 (to Q.-X.Z.). Publisher Copyright: {\textcopyright} 2021 Yu et al.",

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AU - Yu, Cheng Long

AU - Li, Jin Nan

AU - Gan, Ping

AU - Wang, Li Ping

AU - Yang, Yue Xiong

AU - Yu, Da Fu

AU - Mao, Rong Rong

AU - Xu, Fu Qiang

AU - Zhou, Qi Xin

AU - Richter-Levin, Gal

AU - Xu, Lin

AU - Zhou, Heng

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PY - 2021

Y1 - 2021

N2 - Circuit compensation is often observed in patients with acute ischemic stroke, suggesting the importance of the interaction between brain regions. Also, contextual fear memory is an association between multisensory contexts and fearful stimuli, for which the interaction between the hippocampus and the amygdala is believed to be critical. To understand how focal ischemia in one region could influence the other region, we used a modified photo-thrombosis to induce focal ischemia in the hippocampus or the amygdala or both in freely-moving rats. We found that the learning curve and short-term memory (STM) were not affected in the rats although focal ischemia was induced 5 h before learning in either the hippocampus or the amygdala; these were impaired by the induction of ischemia in both the regions. Furthermore, the learning curve and STM were impaired when ischemia was induced 24 h before learning in either the hippocampus or the amygdala when the synaptic transmission was altered in one region because of ischemia in the other region. These results suggest that the circuit compensation between the hippocampus and the amygdala is critical for fear memory acquisition.

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Developing of focal ischemia in the hippocampus or the amygdala reveals a regional compensation rule for fear memory acquisition

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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