Determinants and Effectiveness of BNT162b2 mRNA Vaccination Among Patients with Atopic Dermatitis: A Population-Based Study

Khalaf Kridin, Yochai Schonmann, Erez Onn, Dana Tzur Bitan, Orly Weinstein, Arnon D. Cohen

Research output: Contribution to journalArticlepeer-review


Background: The effectiveness of messenger RNA coronavirus disease 2019 (COVID-19) vaccines in patients with atopic dermatitis (AD) is yet to be delineated. It remains largely unknown how AD-related immunosuppressive medications affect the development of vaccine-induced immunity. Objective: We aimed to evaluate the prevalence of the BNT162b2 messenger RNA vaccine among patients with AD and to assess its effectiveness in protecting against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, COVID-19-associated hospitalization, and mortality. A specific analysis additionally examined whether AD-related immunosuppressive drugs influenced the effectiveness of the vaccine. Methods: A population-based cohort study was performed using the database of Clalit Heath Services, Israel, to follow adult patients with AD. Multivariate Cox and logistic regression analyses were utilized to calculate the adjusted hazard ratio (HR) and odds ratio (OR) of the incident outcomes. Results: As of 26 June, 2021, 58,582 (75.4%) out of 77,682 adult patients with AD completed two BNT162b2 vaccine doses in Israel. Adulthood-onset AD (adjusted OR, 1.34; 95% CI 1.28–1.40; p < 0.001) and moderate-to-severe AD (adjusted OR, 1.13; 95% CI 1.05–1.21; p = 0.001) predicted an increased vaccination rate. Vaccinated patients with AD demonstrated a significantly decreased risk of SARS-CoV-2 infection (adjusted HR, 0.20; 95% CI 0.16–0.26; p < 0.001), COVID-19-associated hospitalization (adjusted HR, 0.08; 95% CI 0.04–0.18; p < 0.001), and COVID-19-associated mortality (adjusted HR, 0.04; 95% CI 0.01–0.20; p < 0.001). Exposure to immunosuppressive drugs (n = 597; 0.8% of patients) did not impair the protection against SARS-CoV-2 infection after vaccination (adjusted HR, 0.95; 95% CI 0.13–6.81; p = 0.958). Conclusions: In patients with AD, COVID-19 vaccination is highly effective for a wide range of COVID-19-related outcomes. Immunosuppressive drugs did not impair the effectiveness of the vaccine in preventing SARS-CoV-2 infection in this retrospective analysis.

Original languageEnglish
Pages (from-to)385-392
Number of pages8
JournalAmerican Journal of Clinical Dermatology
Issue number3
StatePublished - May 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).


  • Adult
  • BNT162 Vaccine
  • COVID-19 Vaccines
  • COVID-19/epidemiology
  • Cohort Studies
  • Dermatitis, Atopic/epidemiology
  • Humans
  • RNA, Messenger
  • Retrospective Studies
  • SARS-CoV-2
  • Vaccination
  • Vaccines, Synthetic
  • mRNA Vaccines


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