Detection of cleft lip by early second-trimester transvaginal sonography

Moshe Bronshtein, Israel Blumenfeld, Joseph Kohn, Zeev Blumenfeld

Research output: Contribution to journalArticlepeer-review


Objective: To describe the detection of cleft lip in the early second trimester using transvaginal sonography. Methods: We analyzed retrospectively 14,988 ultrasound examinations conducted for fetal malformations between 12–16 weeks’ gestation. Seventy-five percent of the patients were at low risk for fetal anomalies and 25% were at high risk. Results: Eleven cases of fetal cleft lip with or without cleft palate were detected by transvaginal sonography among 14,988 fetuses (0.07%). In nine cases, no risk factors for cleft lip or palate existed. In six cases, the cleft lip represented an isolated malformation, with no other associated anomaly; in five of these six cases, the pregnancy was terminated. One additional case of a small cleft lip was not detected, for a false-negative rate of 8%. Conclusions: The fetal lips can be scanned by transvaginal sonography in the early second trimester, and fetal cleft lip can be detected in most cases. Early second-trimester detection of cleft lip by transvaginal sonography allows informed parental choice regarding continuing or terminating the affected pregnancy. (Obstet Gynecol 1994;84:73-6).

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalObstetrics and Gynecology
Issue number1
StatePublished - Jul 1994
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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