Cytoplasmic aggregation of mutant FUS causes multistep RNA splicing perturbations in the course of motor neuron pathology

Keyphrases

• Amyotrophic Lateral Sclerosis 100%
• RNA Splicing 100%
• Cytoplasmic Aggregates 100%
• Motor Neuron 100%
• Nuclear Localization 25%
• Neurodegenerative Diseases 25%
• Delocalization 25%
• Molecular Events 25%
• Familial Cases 25%
• Sporadic Cases 25%
• Sequestration 25%
• RNA Metabolism 25%
• Mutant Protein 25%
• Intron Retention 25%
• Splicing Pattern 25%
• Neuron-specific 25%
• Proteinopathy 25%
• Microexons 25%
• Exon Splicing 25%
• FUS mutation 25%
• Cryptic Exon 25%
• RNA Splicing Defects 25%
• RNA-binding Protein FUS 25%

Biochemistry, Genetics and Molecular Biology

• RNA Splicing 100%
• Motor Neuron 100%
• FUS 100%
• RNA-binding Protein 10%
• Dynamics 10%
• Exon 10%
• Mutant Protein 10%
• RNA Metabolism 10%
• Amyloid Protein 10%
• Proteinopathy 10%
• Splicing Defect 10%
• Intron Retention 10%

Neuroscience

• RNA Splicing 100%
• Amyotrophic Lateral Sclerosis 80%
• Neurodegenerative Disorder 20%
• Exon 20%
• RNA Metabolism 20%
• Amyloid Protein 20%
• Mutant Protein 20%
• Intron Retention 20%
• Splicing Defect 20%
• RNA Binding Protein FUS 20%