Cytological diagnosis of primary leiomyosarcoma of bone: Case report

Isaac Cohen, Norman Loberant, Moshe Goldfeld, Gershon Volpin

Research output: Contribution to journalArticlepeer-review


We report on a case of primary leiomyosarcoma of the bone in a 77-yr-old man. The patient presented with a painful, enlarging mass in the left shoulder of 6 mo duration. Radiography and computed tomography (CT) revealed a large destructive intramedullary lesion of the proximal humerus, with massive extension into the surrounding soft tissues. CT-guided fine-needle aspiration biopsies (FNAB) of both the bony and soft-tissue lesions were performed. Cytological examination showed a neoplastic process composed of spindle cells mixed with pleomorphic cells. The smooth muscle origin of the neoplastic cells was confirmed by immunocytochemical analysis. We describe the cytological features of this rare primary tumor of bone, and consider the differential diagnosis of spindle-cell neoplasms. Diagn. Cytophatol.

Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalDiagnostic Cytopathology
Issue number4
StatePublished - 2001
Externally publishedYes


  • Bone tumor
  • Cytological diagnosis
  • Leiomyosarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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