Cytochrome b gene selection of subterranean rodent Gansu zokor Eospalax cansus (Rodentia, Spalacidae)

Tongzuo Zhang; Gonghua Lin; Eviatar Nevo; Chuanhua Yang; Jianping Su

doi:10.1016/j.jcz.2012.04.002

Cytochrome b gene selection of subterranean rodent Gansu zokor Eospalax cansus (Rodentia, Spalacidae)

Tongzuo Zhang, Gonghua Lin, Eviatar Nevo, Chuanhua Yang, Jianping Su

Department of Evolutionary and Environmental Biology

Research output: Contribution to journal › Article › peer-review

Abstract

We analyzed the molecular selection of a typical subterranean rodent Gansu zokor (Eospalax cansus) combined with mitochondrial cytochrome b (cytb) and D-loop sequences. A total of 121 samples (from 12 sites belonging to 3 main geographical units: U1, U2, and U3) were sequenced, from which 40 cytb haplotypes and 53 D-loop haplotypes were identified. The results of our tests from two site-specific models (M2a and M8) and one branch-site model (Clade model C) suggest that the evolution of cytb in Gansu zokor is chiefly governed by purifying selection. Moreover, the distribution of non-synonymous mutations and the tests by Clade model C indicated the cytb in U3, where the zokors were confronted with more severe hypoxia because of higher altitude and a colder, drier climate, were facing a higher purifying selection pressure than those in U1 and U2.

Original language	English
Pages (from-to)	118-122
Number of pages	5
Journal	Zoologischer Anzeiger
Volume	252
Issue number	1
DOIs	https://doi.org/10.1016/j.jcz.2012.04.002
State	Published - Mar 2013

Bibliographical note

Funding Information:
This study was supported by the General Programs of the National Natural Science Foundation of China (Nos. 31101628 and 30970366 ), the Training Qualified People Plan “Hope of the West China” of the Chinese Academy of Sciences (CAS) (No. O954021211 ), and the CAS President Scholarship (to G. Lin). E. Nevo thanks the Ancel Teicher Research Foundation of Genetics and Molecular Evolution for financial support. We also thank Robin Permut for her assistance in editing.

Keywords

Cytochrome B
Hypoxia
Purifying selection

ASJC Scopus subject areas

Animal Science and Zoology

Access to Document

10.1016/j.jcz.2012.04.002

Cite this

@article{eeb7c9449713470f8ecb683e44f45d3a,

title = "Cytochrome b gene selection of subterranean rodent Gansu zokor Eospalax cansus (Rodentia, Spalacidae)",

abstract = "We analyzed the molecular selection of a typical subterranean rodent Gansu zokor (Eospalax cansus) combined with mitochondrial cytochrome b (cytb) and D-loop sequences. A total of 121 samples (from 12 sites belonging to 3 main geographical units: U1, U2, and U3) were sequenced, from which 40 cytb haplotypes and 53 D-loop haplotypes were identified. The results of our tests from two site-specific models (M2a and M8) and one branch-site model (Clade model C) suggest that the evolution of cytb in Gansu zokor is chiefly governed by purifying selection. Moreover, the distribution of non-synonymous mutations and the tests by Clade model C indicated the cytb in U3, where the zokors were confronted with more severe hypoxia because of higher altitude and a colder, drier climate, were facing a higher purifying selection pressure than those in U1 and U2.",

keywords = "Cytochrome B, Hypoxia, Purifying selection",

author = "Tongzuo Zhang and Gonghua Lin and Eviatar Nevo and Chuanhua Yang and Jianping Su",

note = "Funding Information: This study was supported by the General Programs of the National Natural Science Foundation of China (Nos. 31101628 and 30970366 ), the Training Qualified People Plan “Hope of the West China” of the Chinese Academy of Sciences (CAS) (No. O954021211 ), and the CAS President Scholarship (to G. Lin). E. Nevo thanks the Ancel Teicher Research Foundation of Genetics and Molecular Evolution for financial support. We also thank Robin Permut for her assistance in editing.",

year = "2013",

month = mar,

doi = "10.1016/j.jcz.2012.04.002",

language = "English",

volume = "252",

pages = "118--122",

journal = "Zoologischer Anzeiger",

issn = "0044-5231",

publisher = "Urban und Fischer Verlag Jena",

number = "1",

}

TY - JOUR

T1 - Cytochrome b gene selection of subterranean rodent Gansu zokor Eospalax cansus (Rodentia, Spalacidae)

AU - Zhang, Tongzuo

AU - Lin, Gonghua

AU - Nevo, Eviatar

AU - Yang, Chuanhua

AU - Su, Jianping

N1 - Funding Information: This study was supported by the General Programs of the National Natural Science Foundation of China (Nos. 31101628 and 30970366 ), the Training Qualified People Plan “Hope of the West China” of the Chinese Academy of Sciences (CAS) (No. O954021211 ), and the CAS President Scholarship (to G. Lin). E. Nevo thanks the Ancel Teicher Research Foundation of Genetics and Molecular Evolution for financial support. We also thank Robin Permut for her assistance in editing.

PY - 2013/3

Y1 - 2013/3

N2 - We analyzed the molecular selection of a typical subterranean rodent Gansu zokor (Eospalax cansus) combined with mitochondrial cytochrome b (cytb) and D-loop sequences. A total of 121 samples (from 12 sites belonging to 3 main geographical units: U1, U2, and U3) were sequenced, from which 40 cytb haplotypes and 53 D-loop haplotypes were identified. The results of our tests from two site-specific models (M2a and M8) and one branch-site model (Clade model C) suggest that the evolution of cytb in Gansu zokor is chiefly governed by purifying selection. Moreover, the distribution of non-synonymous mutations and the tests by Clade model C indicated the cytb in U3, where the zokors were confronted with more severe hypoxia because of higher altitude and a colder, drier climate, were facing a higher purifying selection pressure than those in U1 and U2.

AB - We analyzed the molecular selection of a typical subterranean rodent Gansu zokor (Eospalax cansus) combined with mitochondrial cytochrome b (cytb) and D-loop sequences. A total of 121 samples (from 12 sites belonging to 3 main geographical units: U1, U2, and U3) were sequenced, from which 40 cytb haplotypes and 53 D-loop haplotypes were identified. The results of our tests from two site-specific models (M2a and M8) and one branch-site model (Clade model C) suggest that the evolution of cytb in Gansu zokor is chiefly governed by purifying selection. Moreover, the distribution of non-synonymous mutations and the tests by Clade model C indicated the cytb in U3, where the zokors were confronted with more severe hypoxia because of higher altitude and a colder, drier climate, were facing a higher purifying selection pressure than those in U1 and U2.

KW - Cytochrome B

KW - Hypoxia

KW - Purifying selection

UR - http://www.scopus.com/inward/record.url?scp=84875371125&partnerID=8YFLogxK

U2 - 10.1016/j.jcz.2012.04.002

DO - 10.1016/j.jcz.2012.04.002

M3 - Article

AN - SCOPUS:84875371125

SN - 0044-5231

VL - 252

SP - 118

EP - 122

JO - Zoologischer Anzeiger

JF - Zoologischer Anzeiger

IS - 1

ER -

Cytochrome b gene selection of subterranean rodent Gansu zokor Eospalax cansus (Rodentia, Spalacidae)

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this