Coupling of SARS-CoV-2 to Aβ Amyloid Fibrils

Francesco Coppola, Tomáš Pavlíček, Petr Král

Research output: Contribution to journalArticlepeer-review

Abstract

The COVID-19 infection has been more problematic for individuals with certain health predispositions. Coronaviruses could also interfere with neural diseases if the viruses succeed in entering the brain. Therefore, it might be of principal interest to examine a possible coupling of coronaviruses and amyloid fibrils. Here, molecular dynamics simulations were used to investigate direct coupling of SARS-CoV-2 and Aβ fibrils, which play a central role in neural diseases. The simulations revealed several stable binding configurations and their dynamics of Aβ42 fibrils attached to spike proteins of the Omicron and Alpha variants of SARS-CoV-2.

Original languageEnglish
Pages (from-to)9295-9299
Number of pages5
JournalACS Omega
Volume9
Issue number8
DOIs
StatePublished - 27 Feb 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Published by American Chemical Society.

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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