The model demonstrates a tDCS-induced alteration of synaptic vesicle release. tDCS induces a small variation in terminal membrane potential sufficient to activate voltage-gated calcium channels. This initial calcium influx act as a feedback loop for further calcium channels opening, eventually inducing calcium elevation. Calcium concentration control spontaneous vesicle release, instigating a disproportionate vesicle release for a sub-threshold stimulus.
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ASJC Scopus subject areas
- General Neuroscience
- Clinical Neurology