Correlation between malignancy level of AKR lymphoma variants and sensitivity to hyperthermia

J. Leibovici, G. Klorin, O. Klein, M. Michowitz

Research output: Contribution to journalArticlepeer-review


The tumor progression process has been found to be accompanied by various cell membrane modifications. This cell organelle may therefore be considered as a target for drugs directed against tumor cells of advanced cancer. Hyperthermia acts on tumor cells largely, although not only, via an effect on the cell membrane. In the present study, the in vitro effect of hyperthermia on the tumorigenicity of cells derived from two AKR lymphoma variants of malignancy, TAU-39 of low (LM) and TAU-38 of high-malignancy (HM), was compared. The cells of the HM variant were markedly more sensitive to hyperthermic treatment than those of the LM one. Pretreatment of cells at 41°C or 43°C resulted in a more marked delay in tumor appearance in mice injected with the HM than in those inoculated with the LM variant. Moreover, in mice inoculated with cells pretreated at 45°C, long term survivors were found only in those inoculated with the HM variant. These results corroborate our previous data regarding the effect of hyperthermia on metastatic and primary tumor cells of AKR lymphoma as well as the F1 and F10 variants of B16 melanoma.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalCancer Biotherapy
Issue number1
StatePublished - 1995
Externally publishedYes


  • AKR lymphoma
  • Advanced cancer treatment
  • Cell membrane drug targeting
  • Hyperthermia
  • Metastatic potential

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology


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