Correlation between CHA2DS2-VASc score and glaucoma treatment and prognosis

Yoav Y. Pikkel, Daniel Krebs, Vadim Igal, Adi Sharabi-Nov, Irena Epstein, Joseph Pikkel

Research output: Contribution to journalArticlepeer-review


Purpose. To find if CHA2DS2-VASc scale can accurately predict the treatment, prognosis, and outcome for primary open-angle glaucoma (POAG). Patients and methods. A survey of 250,000 patient years was taken, using the records of the Ophthalmology Department at Ziv Medical Center. Data was collected regarding the retinal nerve fiber layer (RNFL), visual field (VF), line of treatment (LOT) of glaucoma, and all the data needed to accurately calculate CHA2DS2-VASc score for each patient. Results. Sixty-seven patients were included in the statistical analysis. The mean age was 72.5 years. The mean CHA2DS2-VASc score was 3.27 + -1.7. Positive Pearson's correlation coefficients were found for LOT and CHA2DS2-VASc score, 0.35, and for RNFL grade and CHA2DS2-VASc score, 0.37. The correlation was negative for RNFL width and CHA2DS2-VASc score, -0.35. Conclusions. CHA2DS2-VASc score was shown to be correlated with glaucoma. This correlation was manifested positively by the LOT needed to stop glaucoma progression, with higher CHA2DS2-VASc scores correlated with more aggressive treatment. Since glaucoma is a disease with a progressing nature, it is important to treat patients aggressively on one hand, while offering the most benign treatment as possible on the other hand. Modification of the CHA2DS2-VASc score could achieve an even higher correlation.

Original languageEnglish
Article number8931430
JournalJournal of Ophthalmology
StatePublished - 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 Yoav Y. Pikkel et al.

ASJC Scopus subject areas

  • Ophthalmology


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