Correlates of taste and taste-aversion learning in the rodent brain

Yadin Dudai, Kobi Rosenblum, Noam Meiri, Ruth Miskin, Rina Schul

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


In conditioned taste aversion (CTA) and taste-potentiated odor aversion (TPOA) individuals learn to associate taste or odor with poisoning. This leads to subsequent aversion to that taste or odor. In nature, the poisoning is due to toxins in the foodstuff; in the laboratory, ip injection of LiCl is usually used to elicit transient malaise. Protein tyrosine phosphorylation is modulated in the course of action of the signal transduction pathways that regulate cellular differentiation and growth. It became apparent that tyrosine phosphorylation also plays a key function in neuronal activity and plasticity. Protein tyrosine phosphorylation, as a posttranslational modification, can persist for only seconds to possibly minutes or hours. Therefore, even when considered as a mechanism of cellular memory, protein tyrosine phosphorylation per se cannot instantiate long-term changes. The observation that protein synthesis is necessary for memory consolidation is construed as indicating that modulation of gene expression is required for the formation of long-term memory.

Original languageEnglish
Title of host publicationPlasticity in the Central Nervous System
Subtitle of host publicationLearning and Memory
PublisherTaylor and Francis
Number of pages9
ISBN (Electronic)9781317729020
ISBN (Print)0805815732, 9780805815733
StatePublished - 1 Jan 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 1995 Taylor & Francis. All rights reserved.

ASJC Scopus subject areas

  • General Psychology


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