Confronting the threat of bioterrorism: realities, challenges, and defensive strategies

Manfred S. Green, James LeDuc, Daniel Cohen, David R. Franz

Research output: Contribution to journalReview articlepeer-review


Global terrorism is a rapidly growing threat to world security, and increases the risk of bioterrorism. In this Review, we discuss the potential threat of bioterrorism, agents that could be exploited, and recent developments in technologies and policy for detecting and controlling epidemics that have been initiated intentionally. The local and international response to infectious disease epidemics, such as the severe acute respiratory syndrome and west African Ebola virus epidemic, revealed serious shortcomings which bioterrorists might exploit when intentionally initiating an epidemic. Development of new vaccines and antimicrobial therapies remains a priority, including the need to expedite clinical trials using new methodologies. Better means to protect health-care workers operating in dangerous environments are also needed, particularly in areas with poor infrastructure. New and improved approaches should be developed for surveillance, early detection, response, effective isolation of patients, control of the movement of potentially infected people, and risk communication. Access to dangerous pathogens should be appropriately regulated, without reducing progress in the development of countermeasures. We conclude that preparedness for intentional outbreaks has the important added value of strengthening preparedness for natural epidemics, and vice versa.

Original languageEnglish
Pages (from-to)e2-e13
JournalThe Lancet Infectious Diseases
Issue number1
StatePublished - Jan 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

ASJC Scopus subject areas

  • Infectious Diseases


Dive into the research topics of 'Confronting the threat of bioterrorism: realities, challenges, and defensive strategies'. Together they form a unique fingerprint.

Cite this