Confidence intervals for the 50 per cent response dose

D. Faraggi, P. Izikson, B. Reiser

Research output: Contribution to journalArticlepeer-review


Confidence intervals for the 50 per cent response dose are usually computed using either the Delta method or Fieller's procedure. Recently, confidence intervals computed by inverting the asymptotic likelihood ratio test have also been recommended. There is some controversy as to which of these methods should be used. By means of an extensive simulation study we examine these methods as well as confidence intervals obtained by the approximate bootstrap confidence (ABC) procedure and an adjusted form of the likelihood ratio based confidence intervals.

Original languageEnglish
Pages (from-to)1977-1988
Number of pages12
JournalStatistics in Medicine
Issue number12
StatePublished - 30 Jun 2003


  • Bioassay
  • Bootstrap
  • Delta method
  • Fieller's method
  • Likelihood ratio
  • Logistic regression

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability


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