Concentration-response relationships between hourly particulate matter and ischemic events: A case-crossover analysis of effect modification by season and air-mass origin

Ronit Nirel; Ilan Levy; Sara D. Adar; Bella Vakulenko-Lagun; Alon Peretz; Michal Golovner; Uri Dayan

doi:10.1016/j.scitotenv.2020.143407

Concentration-response relationships between hourly particulate matter and ischemic events: A case-crossover analysis of effect modification by season and air-mass origin

Ronit Nirel, Ilan Levy, Sara D. Adar, Bella Vakulenko-Lagun, Alon Peretz, Michal Golovner, Uri Dayan

Research output: Contribution to journal › Article › peer-review

Abstract

Most studies linking cardiovascular disease with particulate matter (PM) exposures have focused on total mass concentrations, regardless of their origin. However, the origin of an air mass is inherently linked to particle composition and possible toxicity. We examine how the concentration-response relation between hourly PM exposure and ischemic events is modified by air-mass origin and season. Using telemedicine data, we conducted a case-crossover study of 1855 confirmed ischemic cardiac events in Israel (2005–2013). Based on measurements at three fixed-sites in Tel Aviv and Haifa, ambient PM with diameter < 2.5 μm (PM_2.5) and 2.5–10 μm (PM₁₀_–_2.5) concentrations during the hours before event onset were compared with matched control periods using conditional logistic regression that allowed for non-linearity. We also examined effect modification of these associations based on the geographical origin of each air mass by season. Independent of the geographical origin of the air mass, we observed concentration-response curves that were supralinear. For example, the overall odds ratios (ORs) of ischemic events for an increase of 10-μg/m³ in the 2-h average of PM₁₀_–_2.5 were 1.08 (95% confidence interval (CI): 1.03–1.14) and 1.00 (0.99–1.01) at the median (17.8 μg/m³) and 95th percentile (82.3 μg/m³) values, respectively. Associations were strongest at low levels of PM₁₀_–_2.5 when air comes from central Europe in the summer (OR: 1.27; 95% CI: 1.06, 1.52). Our study demonstrates that hourly associations between PM_2.5 and PM₁₀_–_2.5 and ischemic cardiac events are supralinear during diverse pollution conditions in a single population that experiences a wide range of exposure levels.

Original language	English
Article number	143407
Journal	Science of the Total Environment
Volume	760
DOIs	https://doi.org/10.1016/j.scitotenv.2020.143407
State	Published - 15 Mar 2021
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported in part by the Environment and Health Fund (EHF) (grant number RG1201). The EHF had no involvement in study design, in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the article for publication.

Publisher Copyright:
© 2020 Elsevier B.V.

Keywords

Air mass back-trajectory
Cardiovascular disease
Coarse particulate matter
Exposure-response curve
Short-term exposure
Telemedicine

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
Waste Management and Disposal
Pollution

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.scitotenv.2020.143407

Cite this

Nirel, R., Levy, I., Adar, S. D., Vakulenko-Lagun, B., Peretz, A., Golovner, M., & Dayan, U. (2021). Concentration-response relationships between hourly particulate matter and ischemic events: A case-crossover analysis of effect modification by season and air-mass origin. Science of the Total Environment, 760, Article 143407. https://doi.org/10.1016/j.scitotenv.2020.143407

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abstract = "Most studies linking cardiovascular disease with particulate matter (PM) exposures have focused on total mass concentrations, regardless of their origin. However, the origin of an air mass is inherently linked to particle composition and possible toxicity. We examine how the concentration-response relation between hourly PM exposure and ischemic events is modified by air-mass origin and season. Using telemedicine data, we conducted a case-crossover study of 1855 confirmed ischemic cardiac events in Israel (2005–2013). Based on measurements at three fixed-sites in Tel Aviv and Haifa, ambient PM with diameter < 2.5 μm (PM2.5) and 2.5–10 μm (PM10–2.5) concentrations during the hours before event onset were compared with matched control periods using conditional logistic regression that allowed for non-linearity. We also examined effect modification of these associations based on the geographical origin of each air mass by season. Independent of the geographical origin of the air mass, we observed concentration-response curves that were supralinear. For example, the overall odds ratios (ORs) of ischemic events for an increase of 10-μg/m3 in the 2-h average of PM10–2.5 were 1.08 (95% confidence interval (CI): 1.03–1.14) and 1.00 (0.99–1.01) at the median (17.8 μg/m3) and 95th percentile (82.3 μg/m3) values, respectively. Associations were strongest at low levels of PM10–2.5 when air comes from central Europe in the summer (OR: 1.27; 95% CI: 1.06, 1.52). Our study demonstrates that hourly associations between PM2.5 and PM10–2.5 and ischemic cardiac events are supralinear during diverse pollution conditions in a single population that experiences a wide range of exposure levels.",

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AU - Vakulenko-Lagun, Bella

AU - Peretz, Alon

AU - Golovner, Michal

AU - Dayan, Uri

N1 - Funding Information: This study was supported in part by the Environment and Health Fund (EHF) (grant number RG1201). The EHF had no involvement in study design, in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the article for publication. Publisher Copyright: © 2020 Elsevier B.V.

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AB - Most studies linking cardiovascular disease with particulate matter (PM) exposures have focused on total mass concentrations, regardless of their origin. However, the origin of an air mass is inherently linked to particle composition and possible toxicity. We examine how the concentration-response relation between hourly PM exposure and ischemic events is modified by air-mass origin and season. Using telemedicine data, we conducted a case-crossover study of 1855 confirmed ischemic cardiac events in Israel (2005–2013). Based on measurements at three fixed-sites in Tel Aviv and Haifa, ambient PM with diameter < 2.5 μm (PM2.5) and 2.5–10 μm (PM10–2.5) concentrations during the hours before event onset were compared with matched control periods using conditional logistic regression that allowed for non-linearity. We also examined effect modification of these associations based on the geographical origin of each air mass by season. Independent of the geographical origin of the air mass, we observed concentration-response curves that were supralinear. For example, the overall odds ratios (ORs) of ischemic events for an increase of 10-μg/m3 in the 2-h average of PM10–2.5 were 1.08 (95% confidence interval (CI): 1.03–1.14) and 1.00 (0.99–1.01) at the median (17.8 μg/m3) and 95th percentile (82.3 μg/m3) values, respectively. Associations were strongest at low levels of PM10–2.5 when air comes from central Europe in the summer (OR: 1.27; 95% CI: 1.06, 1.52). Our study demonstrates that hourly associations between PM2.5 and PM10–2.5 and ischemic cardiac events are supralinear during diverse pollution conditions in a single population that experiences a wide range of exposure levels.

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Concentration-response relationships between hourly particulate matter and ischemic events: A case-crossover analysis of effect modification by season and air-mass origin

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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