Common pathways for growth and for plasticity

Shira Knafo, José A. Esteban

Research output: Contribution to journalReview articlepeer-review


Cell growth and differentiation in developing tissues are, at first impression, quite different endeavors from readjusting synaptic strength during activity-dependent synaptic plasticity in mature neurons. Nevertheless, it is becoming increasingly clear that these two distinct processes share multiple intracellular signaling events. How these common pathways result in cell division (during proliferation), large-scale cellular remodeling (during differentiation) or synapse-specific changes (during synaptic plasticity) is only starting to be elucidated. Here we review the latest findings on two prototypical examples of these shared mechanisms: the Ras-PI3K pathway and the intracellular signaling elicited by neural cell adhesion molecules interacting with growth factor receptors.

Original languageEnglish
Pages (from-to)405-411
Number of pages7
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Jun 2012
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


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