Clinical evaluation of isolated nonvisualized fetal gallbladder

Yifat Ochshorn, Guy Rosner, Dalit Barel, Moshe Bronshtein, Francoise Muller, Yuval Yaron

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Isolated nonvisualized fetal gallbladder (INVFGB) is relatively rare. In most cases, the gallbladder will eventually be detected. In some cases however, INVFGB may be associated with serious abnormalities, cystic fibrosis (CF), aneuploidy, and agenesis of the gall bladder. We describe a clinical evaluation of prenatally diagnosed INVFGB. Methods: Cases of nonvisualized gallbladder were first evaluated by serial scans. Cases with no additional malformations were designated as INVFGB, and were further evaluated by mutation analysis for CF, and amniocentesis for karyotype and microvillar membrane enzymes (MME). Results: A total of 22 cases of nonvisualized gallbladder were detected. Of these, 2 had additional malformations, and 3 were excluded because of incomplete evaluation. Of the remaining 17 cases, 3 (17.6%) had adverse outcomes: 1 case of CF, 1 case of 47,XXX, and 1 case of multiple congenital anomalies detected only postnatally. Abnormal levels of MMEs were detected in 3 cases, 1 of which was diagnosed with CF. In 2 cases, the gallbladder was not detected even after birth, but development is normal. Conclusion: Evaluation of INVFGB should include genetic counselling, amniocentesis for karyotype and MME analysis, CFTR mutation analysis and repeated ultrasound scans.

Original languageEnglish
Pages (from-to)699-703
Number of pages5
JournalPrenatal Diagnosis
Volume27
Issue number8
DOIs
StatePublished - Aug 2007
Externally publishedYes

Keywords

  • Aneuploidy
  • Cystic fibrosis (CF)
  • Isolated nonvisualized gallbladder (INVFGB)
  • Microvillar membrane enzymes (MME)
  • Ultrasound scan

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynecology

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