Circannual variations in blood cholesterol levels

Estela Kristal-Boneh, Gil Harari, Manfred S. Green

Research output: Contribution to journalArticlepeer-review


The seasonality of blood cholesterol is still not well established. Some have described a seasonal pattern with highest levels during autumn and lowest in summer, whereas others have reported no change. A number of studies showed circannual variations with maximum levels in winter and minimum in summer. The aim of this study was to examine the circannual variation of cholesterol in a large cohort in Israel. In the Israeli CORDIS study, employees of 21 factories were screened for cardiovascular disease risk factors during 1985-7. As part of the information gathered, serum cholesterol and blood counts were available for 3,726 men and 1,514 women. Serum cholesterol levels fit a circannual rhythm assessed by the cosinor analysis. Highest levels of serum cholesterol were found in spring and lowest in summer. We conclude that there is a circannual change of serum cholesterol, which could be partially associated with changes in environmental temperature. The circannual variation in serum cholesterol was considerable and should be taken into account when carrying out clinical evaluation of patients.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalChronobiology International
Issue number1
StatePublished - 1993
Externally publishedYes


  • Cholesterol
  • Epidemiology
  • Season

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology


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