Circadian rhythm entrainment in flies and mammals

Rachel Ben-Shlomo, Charalambos P. Kyriacou

Research output: Contribution to journalReview articlepeer-review


Circadian rhythms are a fundamental adaptation of living cells to the daily and seasonal fluctuation in light and temperature. Circadian oscillations persist in constant conditions; however, they are also phase-adjusted (entrained) by day-night cycles. It is this entrainability that provides for the proper phasing of the program, to the sequence of external changes that it has evolved to exploit. Synchronization of circadian oscillators with the outside world is achieved because light, temperature, or other external temporal cues, have acute effects on the levels of one or more of the clock's components. The consequences are ripples through the interconnected molecular loops, leading to a stable phase realignment of the endogenous rhythm generator and the external conditions. This review summarized the evolving knowledge of the different types, modes, and molecular processes of entrainment in flies and mammals.

Original languageEnglish
Pages (from-to)141-156
Number of pages16
JournalCell Biochemistry and Biophysics
Issue number2
StatePublished - Oct 2002


  • Chronobiology
  • Circadian rhythm
  • Clock genes
  • Entrainment

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology


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